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9/28/2015 11:46:00 AM | Browse: 336 | Download: 605
Publication Name World Journal of Gastroenterology
Manuscript ID 17786
Country of Manuscript Source Taiwan
2015-03-24 17:34
Peer-Review Started
2015-03-26 17:45
To Make the First Decision
2015-05-18 12:39
Return for Revision
2015-05-19 16:58
2015-05-26 11:22
Second Decision
2015-07-27 20:09
Accepted by Journal Editor-in-Chief
2015-07-29 09:33
Accepted by Company Editor-in-Chief
2015-08-31 16:03
Articles in Press
2015-08-31 16:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-09-09 17:31
Publish the Manuscript Online
2015-09-28 11:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Topic Highlights
Article Title Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: Are we getting there?
Manuscript Source Invited Manuscript
All Author List Yu-Yun Shao, Chih-Hung Hsu and Ann-Lii Cheng
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Council, Taiwan NSC-101-2314-B-002-141
National Science Council, Taiwan NSC-102-2314-B-002-120
Ministry of Science and Technology, Taiwan MOST-103-2314-B-002-181-MY2
Ministry of Science and Technology, Taiwan MOST-103-2314-B-002-090
Ministry of Science and Technology, Taiwan MOST -103-2314-B-002-092
Correspondence To Chih-Hung Hsu, MD, PhD, Department of Oncology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 10002, Taiwan. chihhunghsu@ntu.edu.tw
Keywords Hepatocellular carcinoma; Predictive marker; Prognosis; Sorafenib
Core Tip A predictive biomarker of sorafenib efficacy in advanced hepatocellular carcinoma is a clinical unmet need. Previous studies identified the potential of blood levels of angiopoietin-2, hepatocyte growth factor, insulin-like growth factor-1, and transforming growth factor-β1 for predicting sorafenib efficacy. Alpha-fetoprotein response, dynamic contrast-enhanced magnetic resonance imaging, and treatment-related side effects may serve as early surrogate markers. Novel approaches based on super-responders or experimental mouse models may provide new research directions. A group effort that considers various prognostic factors and proper collection of tumor tissues before treatment is imperative for the success of future biomarker research in advanced hepatocellular carcinoma.
Publish Date 2015-09-28 11:42
Citation Shao YY, Hsu CH, Cheng AL. Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: Are we getting there? World J Gastroenterol 2015; 21(36): 10336-10347
Url http://www.wjgnet.com/1007-9327/full/v21/i36/10336.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i36.10336
Full Article (PDF) WJG-21-10336.pdf
Full Article (Word) WJG-21-10336.doc
Revised Manuscript 17786-Review.doc
Peer-review Report 17786-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17786-Journal editor-in-chief review report.pdf
Answering Reviewers 17786-Answering reviewers.pdf
Scientific Misconduct Check 17786-Scientific misconduct check.pdf
Scientific Editor Work List 17786-Scientific editor work list.pdf
Audio Core Tip 17786-Audio core tip.wav
Conflict-of-Interest Disclosure Form 17786-Conflict-of-interest statement.pdf
Copyright License Agreement 17786-Copyright assignment.pdf