Publication Name	World Journal of Gastroenterology
Manuscript ID	17791
Country	Japan

Received	2015-03-24 17:12
Peer-Review Started	2015-03-27 08:31
First Decision by Editorial Office Director
Return for Revision	2015-05-19 17:08
Revised	2015-06-01 18:00
Publication Fee Transferred
Second Decision by Editor	2015-07-14 21:10
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-07-15 14:17
Articles in Press	2015-07-15 14:17
Edit the Manuscript by Language Editor	2015-08-19 01:08
Typeset the Manuscript	2015-09-01 12:15
Publish the Manuscript Online	2015-09-18 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Effect of tumor necrosis factor-α antagonists on oxidative stress in patients with Crohn’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Kazunari Yamamoto, Toshimi Chiba and Takayuki Matsumoto
Funding Agency and Grant Number
Corresponding Author	Kazunari Yamamoto, MD, Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Uchimaru 19-1, Morioka City, Iwate 020-8505, Japan. m77_ky@yahoo.co.jp
Key Words	Crohn’s disease; severity; oxidative stress; anti-TNFα antibodies
Core Tip	We measured serum markers of oxidative stress (d-ROM) and antioxidant potential (BAP) prior to and eight weeks after the initial administration of infliximab or adalimumab in Crohn’s disease. As a consequence, d-ROM decreased significantly after the treatment. However, BAP and the ratio of oxidative stress and antioxidant potential remained unchanged. Anti--tumor necrosis factor-α therapy decreases oxidative stress, but does not alter the production of antioxidants. Dysregulation of antioxidants may be associated with Crohn’s disease.
Publish Date	2015-09-18 10:11
Citation	Yamamoto K, Chiba T, Matsumoto T. Effect of tumor necrosis factor-α antagonists on oxidative stress in patients with Crohn’s disease. World J Gastroenterol 2015; 21(35): 10208-10214
URL	http://www.wjgnet.com/1007-9327/full/v21/i35/10208.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i35.10208

Full Article (PDF)	WJG-21-10208.pdf
Full Article (Word)	WJG-21-10208.doc
Manuscript File	17791-Review.docx
Answering Reviewers	17791-Answering reviewers.pdf
Audio Core Tip	17791-Audio core tip.mp3
Copyright License Agreement	17791-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	17791-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	17791-Language certificate.pdf
Peer-review Report	17791-Peer-review(s).pdf
Scientific Misconduct Check	17791-Scientific misconduct check.pdf
Scientific Editor Work List	17791-Scientific editor work list.pdf