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11/27/2015 2:08:00 PM | Browse: 471 | Download: 1126
Publication Name World Journal of Gastroenterology
Manuscript ID 17833
Country of Manuscript Source Turkey
Received
2015-03-26 08:11
Peer-Review Started
2015-03-28 15:12
To Make the First Decision
2015-05-18 12:43
Return for Revision
2015-05-19 17:46
Revised
2015-06-05 05:04
Second Decision
2015-09-12 21:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-14 11:00
Articles in Press
2015-09-14 11:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-30 14:49
Publish the Manuscript Online
2015-11-27 14:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model
Manuscript Source Unsolicited Manuscript
All Author List Gozde Dervis Hakim, Mujde Soyturk, Mehtat Unlu, Pinar Ataca, Meral Karaman, Ozgul Sagol, Elif Borekci and Osman Yilmaz
Funding Agency and Grant Number
Funding Agency Grant Number
Dokuz Eylul University Research Committee
Corresponding author Gozde Dervis Hakim, MD, Department of Gastroenterology, School of Medicine, Dokuz Eylul University, Inciralti, Mh., Mithatpaşa cad. No. 1606, İnciraltı yerleşkesi, Izmir 35340, Turkey. gozdedervis@gmail.com
Keywords Inflammatory bowel disease; Enterocolitis; Platelet-derived growth factor receptor; Tumor necrosis factor α; Tyrosine kinase inhibitor; Rats; Mucosal healing
Core Tip The etiopathogenesis of inflammatory bowel diseases (IBDs) has not been clearly elucidated. Many management strategies that include targeting particular pathways involved in the development of IBD have been developed. In the present study, we aimed to investigate the effects of nilotinib in a rat model of indomethacin-induced enterocolitis. From our study, it appears that nilotinib had considerable effects on pathological scores, which indicated positive effects in mucosal healing. Nilotinib decreased platelet-derived growth factor receptor α and β and increased the colonic apoptotic scores, but it had no significant effects on weight loss or serum-tissue tumor necrosis factor α levels.
Publish Date 2015-11-27 14:01
Citation Dervis Hakim G, Soyturk M, Unlu M, Ataca P, Karaman M, Sagol O, Borekci E, Yilmaz O. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol 2015; 21(44): 12576-12585
Url http://www.wjgnet.com/1007-9327/full/v21/i44/12576.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i44.12576
Full Article (PDF) WJG-21-12576.pdf
Full Article (Word) WJG-21-12576.doc
Manuscript File 17833-Review.doc
Answering Reviewers 17833-Answering reviewers.pdf
Audio Core Tip 17833-Audio core tip.mp3
Biostatistics Review Certificate 17833-Biostatistics statement.pdf
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20150326022134.pdf
Conflict-of-Interest Disclosure Form 17833-Conflict-of-interest statement.pdf
Copyright License Agreement 17833-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 17833-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document Institutional_Review_Board_Statement_20150326021903.pdf
Non-Native Speakers of English Editing Certificate 17833-Language certificate.pdf
Supplementary Material 17833-Supplementary Material.docx
Peer-review Report 17833-Peer-review(s).pdf
Scientific Misconduct Check 17833-Scientific misconduct check.pdf
Scientific Editor Work List 17833-Scientific editor work list.pdf