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Articles Published Processes
11/27/2015 2:08:00 PM | Browse: 1257 | Download: 3092
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Received |
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2015-03-26 08:11 |
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Peer-Review Started |
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2015-03-28 15:12 |
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To Make the First Decision |
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2015-05-18 12:43 |
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Return for Revision |
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2015-05-19 17:46 |
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Revised |
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2015-06-05 05:04 |
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Second Decision |
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2015-09-12 21:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-09-14 11:00 |
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Articles in Press |
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2015-09-14 11:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-30 14:49 |
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Publish the Manuscript Online |
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2015-11-27 14:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gozde Dervis Hakim, Mujde Soyturk, Mehtat Unlu, Pinar Ataca, Meral Karaman, Ozgul Sagol, Elif Borekci and Osman Yilmaz |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Dokuz Eylul University Research Committee |
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| Corresponding Author |
Gozde Dervis Hakim, MD, Department of Gastroenterology, School of Medicine, Dokuz Eylul University, Inciralti, Mh., Mithatpaşa cad. No. 1606, İnciraltı yerleşkesi, Izmir 35340, Turkey. gozdedervis@gmail.com
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| Key Words |
Inflammatory bowel disease; Enterocolitis; Platelet-derived growth factor receptor; Tumor necrosis factor α; Tyrosine kinase inhibitor; Rats; Mucosal healing |
| Core Tip |
The etiopathogenesis of inflammatory bowel diseases (IBDs) has not been clearly elucidated. Many management strategies that include targeting particular pathways involved in the development of IBD have been developed. In the present study, we aimed to investigate the effects of nilotinib in a rat model of indomethacin-induced enterocolitis. From our study, it appears that nilotinib had considerable effects on pathological scores, which indicated positive effects in mucosal healing. Nilotinib decreased platelet-derived growth factor receptor α and β and increased the colonic apoptotic scores, but it had no significant effects on weight loss or serum-tissue tumor necrosis factor α levels.
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| Publish Date |
2015-11-27 14:01 |
| Citation |
Dervis Hakim G, Soyturk M, Unlu M, Ataca P, Karaman M, Sagol O, Borekci E, Yilmaz O. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol 2015; 21(44): 12576-12585 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i44/12576.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i44.12576 |
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