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8/20/2015 1:37:00 PM | Browse: 863 | Download: 2278
Publication Name World Journal of Gastroenterology
Manuscript ID 17870
Country/Territory South Korea
Received
2015-03-27 17:15
Peer-Review Started
2015-03-28 18:48
To Make the First Decision
2015-06-02 13:29
Return for Revision
2015-06-06 15:04
Revised
2015-06-22 08:52
Second Decision
2015-06-26 09:47
Accepted by Journal Editor-in-Chief
2015-06-29 15:29
Accepted by Company Editor-in-Chief
2015-07-03 17:01
Articles in Press
2015-07-03 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-08-05 14:49
Publish the Manuscript Online
2015-08-20 13:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pathology
Manuscript Type Basic Study
Article Title Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Byung Joon Choi, Jung Hwan Yoon, Olga Kim, Won Suk Choi, Suk Woo Nam, Jung Young Lee and Won Sang Park
Funding Agency and Grant Number
Funding Agency Grant Number
Basic Science Research Programs 2012R1A2A2A01002531
Corresponding Author Won Sang Park, MD, PhD, Professor of Medicine, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea. wonsang@catholic.ac.kr
Key Words Human telomerase reverse transcriptase; Telomere; Gastric cancer; Polymorphism; Risk
Core Tip The rs2736100 polymorphism is closely associated with reduced human telomerase reverse transcriptase (hTERT) mRNA expression and shortened telomere length in gastric cancer tissue and cell lines. Additionally, telomere length and hTERT mRNA levels were significantly increased in those with the C/C genotype in intestinal-type gastric cancer. Notably, there was no significant difference in the genotype and allele frequencies of the rs2736100 polymorphism between the patients with gastric cancer and healthy controls. These results suggest that the rs2736100 polymorphism of the hTERT gene is involved in the regulation of hTERT expression and telomere length, but not in the risk of gastric cancer.
Publish Date 2015-08-20 13:37
Citation Choi BJ, Yoon JH, Kim O, Choi WS, Nam SW, Lee JY, Park WS. Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer. World J Gastroenterol 2015; 21(31): 9328-9336
URL http://www.wjgnet.com/1007-9327/full/v21/i31/9328.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i31.9328
Full Article (PDF) WJG-21-9328.pdf
Full Article (Word) WJG-21-9328.doc
Manuscript File 17870-Review.docx
Answering Reviewers 17870-Answering reviewers.pdf
Audio Core Tip 17870-Audio core tip.mp3
Biostatistics Review Certificate 17870-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 17870-Conflict-of-interest statment.pdf
Copyright License Agreement 17870-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20150327134805.pdf
Institutional Animal Care and Use Committee Approval Form or Document 17870-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 17870-Intitutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 17870-Language certificate.pdf
Peer-review Report 17870-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17870-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17870-Scientific misconduct check.pdf
Scientific Editor Work List 17870-Scientific editor work list.pdf