Publication Name	World Journal of Gastroenterology
Manuscript ID	17878
Country	Germany

Received	2015-03-30 14:08
Peer-Review Started	2015-03-30 19:04
First Decision by Editorial Office Director
Return for Revision	2015-06-26 19:34
Revised	2015-07-17 06:32
Publication Fee Transferred
Second Decision by Editor	2015-10-23 16:33
Second Decision by Editor-in-Chief	2015-10-24 04:11
Final Decision by Editorial Office Director	2015-11-09 17:18
Articles in Press	2015-11-09 17:18
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-02 08:50
Publish the Manuscript Online	2016-01-06 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview
Manuscript Source	Invited Manuscript
All Author List	Vilma Oliveira Frick, Claudia Rubie, Ulrich Keilholz and Pirus Ghadjar
Funding Agency and Grant Number
Corresponding Author	Vilma Oliveira Frick, PhD, Department of General-, Visceral-, Vascular- and Pediatric Surgery, University of the Saarland, Building 57, 66421 Homburg/Saar, Germany. vilma.frick@uks.eu
Key Words	Chemokine/chemokine receptor pair; CCR6; Chemokine ligand 20; Colorectal cancer; Metastasis; Liver
Core Tip	Here we review the current literature published with respect to the expression pattern of chemokine/chemokine receptor pair cysteine motif chemokine ligand 20 (CCL20)/CCR6 and their physiological interactions as well as the currently presumed role of the CCL20/CCR6 system in the onset and development of colorectal cancer (CRC) and its apparent role in the organ-selective metastatic spread of CRC cells to the liver. Disrupting the chemokine/chemokine receptor interaction of CCL20/CCR6 may therefore be a promising novel treatment strategy in CRC and metastasis.
Publish Date	2016-01-06 16:13
Citation	Frick VO, Rubie C, Keilholz U, Ghadjar P. Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview. World J Gastroenterol 2016; 22(2): 833-841
URL	http://www.wjgnet.com/1007-9327/full/v22/i2/833.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i2.833

Full Article (PDF)	WJG-22-833.pdf
Full Article (Word)	WJG-22-833.doc
Manuscript File	17878-Review.docx
Answering Reviewers	17878-Answering reviewers.pdf
Audio Core Tip	17878-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17878-Conflict-of-interest statement.pdf
Copyright License Agreement	17878-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20150327191100.docx
Supplementary Material	Supplementary_Material_20150327190912.docx
Peer-review Report	17878-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17878-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17878-Scientific misconduct check.pdf
Scientific Editor Work List	17878-Scientific editor work list.pdf