Publication Name	World Journal of Gastroenterology
Manuscript ID	17892
Country	China

Received	2015-03-29 13:14
Peer-Review Started	2015-03-29 15:11
To Make the First Decision	2015-04-24 19:23
Return for Revision	2015-07-02 21:10
Revised	2015-07-04 15:23
Second Decision	2015-08-21 13:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-15 14:28
Articles in Press	2015-09-15 14:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-10-07 23:50
Typeset the Manuscript	2015-11-04 16:27
Publish the Manuscript Online	2015-12-06 13:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Chemosensitization of HepG2 cells by suppression of NF-κB/p65 gene transcription with specific-siRNA
Manuscript Source	Unsolicited Manuscript
All Author List	Yun Shi, Si-Ye Wang, Min Yao, Wen-Li Sai, Wei Wu, Jun-Ling Yang, Yin Cai, Wen-Jie Zheng and Deng-Fu Yao
Funding Agency and Grant Number	Funding Agency Grant Number Jiangsu Provincial Special Programs of Medical Science BL2012053 Jiangsu Provincial Special Programs of Medical Science HK201102 Nantong Undertaking and Technological Innovation HS2013007 Nantong Undertaking and Technological Innovation BK2013048 Nantong Undertaking and Technological Innovation HS2014078 riority Academic Program Development of Higher Education Institution of Jiangsu Province, the National Natural Science Foundation 81200634 international S &T Cooperation Program of China 2013DFA32150
Corresponding Author	Deng-Fu Yao, MD, PhD, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Key Words	Hepatocellular carcinoma; Nuclear factor-κB; Multidrug-resistant; Chemosensitization; Small interference RNA; P-glycoprotein
Core Tip	Hepatic nuclear factor-kappa B (NF-κB) signaling pathway could be a potential target for designing highly effective therapeutic agents for the chemoprevention of hepatocellular carcinoma (HCC). Specific siRNAs used in combination with doxorubicin could enhance doxorubicin cytotoxicity in human HepG2 cells by downregulating NF-κB and P-glycoprotein expression. Stable NF-κB inhibition and chemosensitization could significantly inhibit tumor cell proliferation. Thus, the modulation of NF-κB might represent an advance in HCC therapy efficacy and is worthy of further research and investigation.
Publish Date	2015-12-06 13:18
Citation	Shi Y, Wang SY, Yao M, Sai WL, Wu W, Yang JL, Cai Y, Zheng WJ, Yao DF. Chemosensitization of HepG2 cells by suppression of NF-κB/p65 gene transcription with specific-siRNA. World J Gastroenterol 2015; 21(45): 12814-12821
URL	http://www.wjgnet.com/1007-9327/full/v21/i45/12814.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i45.12814

Full Article (PDF)	WJG-21-12814.pdf
Full Article (Word)	WJG-21-12814.doc
Manuscript File	17892-Review.doc
Answering Reviewers	17892-Answering reviewers.pdf
Audio Core Tip	17892-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	17892-Conflict-of-interest statement.pdf
Copyright License Agreement	17892-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	17892-Language certificate.pdf
Peer-review Report	17892-Peer-review(s).pdf
Scientific Misconduct Check	17892-Scientific misconduct check.pdf
Scientific Editor Work List	17892-Scientific editor work list.pdf