Publication Name	World Journal of Rheumatology
Manuscript ID	17931
Country	India

Received	2015-03-30 17:22
Peer-Review Started	2015-03-31 20:20
To Make the First Decision	2015-04-27 15:51
Return for Revision	2015-04-28 19:09
Revised	2015-05-24 19:19
Second Decision	2015-06-08 11:39
Accepted by Journal Editor-in-Chief	2015-06-11 00:10
Accepted by Executive Editor-in-Chief	2015-07-14 09:47
Articles in Press	2015-07-14 09:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-30 20:27
Publish the Manuscript Online	2015-11-13 15:40

ISSN	2220-3214 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Rheumatology
Manuscript Type	Review
Article Title	Scleroderma: Not an orphan disease any more
Manuscript Source	Invited Manuscript
All Author List	Durga Prasanna Misra, Abhra Chandra Chowdhury, Sanat Phatak and Vikas Agarwal
Funding Agency and Grant Number
Corresponding Author	Dr. Vikas Agarwal, Additional Professor, Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India. vikasagr@yahoo.com
Key Words	Pulmonary hypertension; Scleroderma; Interstitial lung disease; Raynauds phenomenon; Fibrosis
Core Tip	Scleroderma is a rare disease associated with significant morbidity and mortality. Better understanding regarding its pathogenesis has led to exploration of various newer therapeutic targets. Anti B cell therapy, endothelin receptor antagonists, phosphodiesterase-5 (PDE-5) inhibitors and autologous stem cell transplant holds promise in the management of systemic sclerosis. PDE-5 inhibitors in particular have potential to be disease modifying agents as they not only improve Raynaud’s phenomenon, but also heal digital ulcers, improve pulmonary hypertension and in addition by virtue of antifibrotic properties may have beneficial effect on skin and lung fibrosis.
Publish Date	2015-11-13 15:40
Citation	Misra DP, Chowdhury AC, Phatak S, Agarwal V. Scleroderma: Not an orphan disease any more. World J Rheumatol 2015; 5(3): 131-141
URL	http://www.wjgnet.com/2220-3214/full/v5/i3/131.htm
DOI	http://dx.doi.org/10.5499/wjr.v5.i3.131

Full Article (PDF)	WJR-5-131.pdf
Full Article (Word)	WJR-5-131.doc
Manuscript File	17931-Review.docx
Answering Reviewers	17931-Answering reviewers.pdf
Audio Core Tip	17931-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17931-Conflict-of-interest statement.pdf
Copyright License Agreement	17931-Copyright assignment.pdf
Peer-review Report	17931-Peer-review(s) .pdf
Journal Editor-in-Chief Review Report	17931-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17931-Scientific misconduct check.pdf
Scientific Editor Work List	17931-Scientific editor work list.pdf