Publication Name	World Journal of Gastroenterology
Manuscript ID	17935
Country	Japan

Received	2015-03-30 17:27
Peer-Review Started	2015-03-31 09:44
To Make the First Decision	2015-05-18 12:09
Return for Revision	2015-05-22 10:14
Revised	2015-05-30 15:33
Second Decision	2015-08-12 10:49
Accepted by Journal Editor-in-Chief	2015-08-14 09:46
Accepted by Executive Editor-in-Chief	2015-08-31 16:08
Articles in Press	2015-08-31 16:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-08 09:19
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy
Manuscript Source	Invited Manuscript
All Author List	Shogo Ohkoshi, Masahiko Yano and Yasunobu Matsuda
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research (C) from the Japan Society for the promotion of Science 22590722 to Ohkoshi S
Corresponding Author	Shogo Ohkoshi, MD, PhD, Professor of Internal Medicine, School of Life Dentistry at Niigata, The Nippon Dental University, 1-8Hamaura-Cho, Chuo-ku, Niigata 951-8580, Japan. okoshi@ngt.ndu.ac.jp
Key Words	p21; Tumor suppressors; Oncogene; Subcellular localization; Hepatocellular carcinoma; HBx; Nucleo-cytoplasmic export; Chromosome region maintenance 1; Selective inhibitors of nuclear export; Interferon
Core Tip	A well-known tumor suppressor, p21, can act paradoxically by promoting tumor growth, depending on its subcellular localization. Nuclear p21 may inhibit cell proliferation while cytoplasmic p21 may be associated with anti-apoptotic and oncogenic functions. These conflicting roles are reviewed in the context of the HBx gene and hepatocarcinogenesis. Because most tumor suppressors act in a similar manner to p21, regulation of their nucleo-cytoplasmic export, which is mainly effected via chromosome region maintenance 1, may be a basis for developing a new strategy for anti-hepatocellular carcinoma therapy.
Publish Date	2015-11-11 13:34
Citation	Ohkoshi S, Yano M, Matsuda Y. Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy. World J Gastroenterol 2015; 21(42): 12150-12156
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/12150.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.12150

Full Article (PDF)	WJG-21-12150.pdf
Full Article (Word)	WJG-21-12150.doc
Manuscript File	17935-Review.docx
Answering Reviewers	17935-Answering reviewers.pdf
Audio Core Tip	17935-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17935-Conflict-of-interest statement.pdf
Copyright License Agreement	17935-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	17935-Language certificate.pdf
Peer-review Report	17935-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17935-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17935-Scientific misconduct check.pdf
Scientific Editor Work List	17935-Scientific editor work list.pdf