Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	18001
Country	United States

Received	2015-04-02 08:46
Peer-Review Started	2015-04-02 15:02
To Make the First Decision	2015-06-18 15:29
Return for Revision	2015-06-24 17:17
Revised	2015-07-03 01:59
Second Decision	2015-07-17 08:15
Accepted by Journal Editor-in-Chief	2015-07-19 07:11
Accepted by Executive Editor-in-Chief	2015-07-27 17:10
Articles in Press	2015-07-27 17:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-27 11:07
Publish the Manuscript Online	2015-11-17 12:17

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Elusive liver factor that causes pancreatic α cell hyperplasia: A review of literature
Manuscript Source	Invited Manuscript
All Author List	Run Yu, Yun Zheng, Matthew B Lucas and Yun-Guang Tong
Funding Agency and Grant Number	Funding Agency Grant Number National Cancer Institute of the National Institutes of Health R00CA138914 (YT) National Natural Science Foundation 81372216 (YT)
Corresponding Author	Run Yu, MD, PhD, Carcinoid and Neuroendocrine Tumor Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd, B-131, Los Angeles, CA 90048, United States. run.yu@cshs.org
Key Words	Pancreatic α cell hyperplasia; Humoral factor; Pancreatic neuroendocrine tumors; Digestive system hormone; Liver
Core Tip	Tumors and cancers of the gastrointestinal tract and pancreas are commonly derived from precursor lesions. One of the precursor lesions, reactive pancreatic α cell hyperplasia is caused by glucagon signaling disruption and invariably evolves into pancreatic neuroendocrine tumors. In this article, the existing work on the mechanisms underlying the novel precursor lesion is reviewed. It is clear that the liver secretes a humoral factor regulating pancreatic α cell numbers but the identity of the liver factor remains elusive. Potential approaches to identify the liver factor are discussed.
Publish Date	2015-11-17 12:17
Citation	Yu R, Zheng Y, Lucas MB, Tong YG. Elusive liver factor that causes pancreatic α cell hyperplasia: A review of literature. World J Gastrointest Pathophysiol 2015; 6(4): 131-139
URL	http://www.wjgnet.com/2150-5330/full/v6/i4/131.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i4.131

Full Article (PDF)	WJGP-6-131.pdf
Full Article (Word)	WJGP-6-131.doc
Manuscript File	18001-Review.doc
Answering Reviewers	18001-Answering reviewers.pdf
Audio Core Tip	18001-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18001-Conflict-of-interest statement.pdf
Copyright License Agreement	18001-Copyright assignment.pdf
Peer-review Report	18001-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18001-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18001-Scientific misconduct check.pdf
Scientific Editor Work List	18001-Scientific editor work list.pdf