Publication Name	World Journal of Hepatology
Manuscript ID	18004
Country	United States

Received	2015-04-02 08:42
Peer-Review Started	2015-04-02 13:37
To Make the First Decision	2015-05-13 19:23
Return for Revision	2015-05-19 10:46
Revised	2015-07-30 00:00
Second Decision	2015-10-22 15:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-04 17:00
Articles in Press	2015-11-04 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-11 11:08
Publish the Manuscript Online	2015-11-18 11:12

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatocellular carcinoma: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Lisa P Waller, Vrushak Deshpande and Nikolaos Pyrsopoulos
Funding Agency and Grant Number
Corresponding Author	Nikolaos Pyrsopoulos, MD, PhD, MBA, FACP, AGAF, Chief of Division of Gastroenterology and Hepatology, Medical Director of Liver Transplantation, Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, MSB H538, 185 South Orange Avenue, Newark, NJ 07103, United States. pyrsopni@njms.rutgers.edu
Key Words	Liver transplantation; Hepatectomy; Milan Criteria; Sorafenib; Living donor liver transplantation; Transarterial chemoembolization; Expansion Milan Criteria; Hepatocellular carcinoma; Mammalian target of rapamycin inhibitors; University of California San Francisco Criteria; Salvage liver transplantation
Core Tip	Hepatocellular carcinoma (HCC) is the pro-minent Primary Hepatic tumor. Survival rates average between 6 and 20 mo, making Liver transplantation is the most efficient treatment. The established Milan Criteria is now widely accepted around the world for choosing patients suffering with HCC as liver transplant candidates. Due to high mortality rates, additional variables and tumor characteristics have been researched (example, University of California, San Francisco Criteria) in order to include more patients as candidates, so as to increase overall survival. In this comprehensive review, the pathophysiology, diagnostic modalities, and treatment options are thoroughly discussed.
Publish Date	2015-11-18 11:12
Citation	Waller LP, Deshpande V, Pyrsopoulos V. Hepatocellular carcinoma: A comprehensive review. World J Hepatol 2015; 7(26): 2648-2663
URL	http://www.wjgnet.com/1948-5182/full/v7/i26/2648.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i26.2648

Full Article (PDF)	WJH-7-2648.pdf
Full Article (Word)	WJH-7-2648.doc
Manuscript File	18004-Review.doc
Answering Reviewers	18004-Answering reviewers.pdf
Audio Core Tip	18004-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	18004-Conflict-of-interest statement.pdf
Copyright License Agreement	18004-Copyright assignment.pdf
Peer-review Report	18004-Peer-review(s).pdf
Scientific Misconduct Check	18004-Scientific misconduct check.pdf
Scientific Editor Work List	18004-Scientific editor work list.pdf