Publication Name	World Journal of Methodology
Manuscript ID	18011
Country	China

Received	2015-04-02 14:54
Peer-Review Started	2015-04-02 17:16
First Decision by Editorial Office Director
Return for Revision	2015-06-09 09:42
Revised	2015-06-16 16:00
Publication Fee Transferred
Second Decision by Editor	2015-06-24 08:26
Second Decision by Editor-in-Chief	2015-06-24 16:53
Final Decision by Editorial Office Director	2015-07-14 09:48
Articles in Press	2015-07-14 09:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-31 19:47
Publish the Manuscript Online	2015-09-16 14:40

ISSN	2222-0682 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Refractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management
Manuscript Source	Invited Manuscript
All Author List	Han-Jing Lv and Zhong-Min Qiu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81170079 National Natural Science Foundation of China 81470276 Shanghai Shenkang Hospital Development Center SHDC12012211
Corresponding Author	Dr. Zhong-Min Qiu, Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, No. 389 Xincun Road, Shanghai 200065, China. qiuzhongmin@tongji.edu.cn
Key Words	Esophageal pH monitoring; Chronic cough; Anti-reflux therapy; Refractory cough; Gastroesophageal reflux
Core Tip	Refractory cough due to reflux can be defined as a reflux-induced cough resistant to standard medical anti-reflux treatment but responsive to the subsequent intensified anti-reflux therapy. It may be associated with the residual acid or non-acid reflux, transient lower esophageal sphincter relaxations and esophageal hypersensitivity. The definite diagnosis of the disorder depends on the positive findings of multi-channel intraluminal impedance-pH monitoring as well as favorable response to the intensified anti-reflux therapy. The current therapeutic strategies include the complete acid suppression and add-on uses of baclofen or gabapentin.
Publish Date	2015-09-16 14:40
Citation	Lv HJ, Qiu ZM. Refractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management. World J Methodol 2015; 5(3): 149-156
URL	http://www.wjgnet.com/2222-0682/full/v5/i3/149.htm
DOI	http://dx.doi.org/10.5662/wjm.v5.i3.14

Manuscript File	18011-Review.doc
Answering Reviewers	18011-Answering reviewers.pdf
Audio Core Tip	18011-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18011-Conflict-of-interest statement.pdf
Copyright License Agreement	18011-Copyright assignment.pdf
Supplementary Material	18011-Supplementary material.pdf
Peer-review Report	18011-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18011-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18011-Scientific misconduct check.pdf
Scientific Editor Work List	18011-Scientific editor work list.pdf