Publication Name	World Journal of Clinical Oncology
Manuscript ID	18028
Country	Saudi Arabia

Received	2015-04-03 08:11
Peer-Review Started	2015-04-05 09:32
To Make the First Decision	2015-05-13 19:24
Return for Revision	2015-05-19 10:59
Revised	2015-07-07 09:11
Second Decision	2015-07-17 08:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-27 17:11
Articles in Press	2015-07-27 17:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-26 18:28
Publish the Manuscript Online	2015-10-13 10:26

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Portal vein embolization effect on colorectal cancer liver metastasis progression: Lessons learned
Manuscript Source	Invited Manuscript
All Author List	Eman Al-Sharif, Eve Simoneau and Mazen Hassanain
Funding Agency and Grant Number
Corresponding Author	Dr. Mazen Hassanain, Associate Professor of Surgery and Consultant Hepatobiliary and Transplant Surgery, Department of Surgery, College of Medicine, Scientific Director Liver Disease Research Centre, King Saud University, PO Box 25179, Riyadh 11466, Saudi Arabia. mhassanain@ksu.edu.sa
Key Words	Tumor growth; Portal vein embolization; Future liver remnant; Colorectal liver metastases; Liver resection; Prevention; Liver hypertrophy
Core Tip	This article discusses the effect of portal vein embolization (PVE) on colorectal liver metastasis (CRLM) growth and the suggested methods of prevention. In addition to presenting the various experimental and clinical studies emphasizing the suggested tumoral enhancing effect of PVE, this article highlights the concept of reversal of chemotherapy response, a potential effect occurring after PVE. This observation may impact significantly subsequent patients’ management as it may affect the resectability state of patients. Moreover, potential methods to prevent tumor growth are discussed in this article, indicating the need for further research in this field and highlighting the complex interaction between CRLM and liver regeneration milieu.
Publish Date	2015-10-13 10:26
Citation	Al-Sharif E, Simoneau E, Hassanain M. Portal vein embolization effect on colorectal cancer liver metastasis progression: Lessons learned. World J Clin Oncol 2015; 6(5): 142-146
URL	http://www.wjgnet.com/2218-4333/full/v6/i5/142.htm
DOI	http://dx.doi.org/10.5306/wjco.v6.i5.142

Full Article (PDF)	WJCO-6-142.pdf
Full Article (Word)	WJCO-6-142.doc
Manuscript File	18028-Review.docx
Answering Reviewers	18028-Answering reviewers.pdf
Audio Core Tip	18028-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18028-Conflict-of-interest statement.pdf
Copyright License Agreement	18028-Copyright assignment.pdf
Peer-review Report	18028-Peer-review(s).pdf
Scientific Misconduct Check	18028-Scientific misconduct check.pdf
Scientific Editor Work List	18028-Scientific editor work list.pdf