Publication Name	World Journal of Gastroenterology
Manuscript ID	18049
Country	Poland

Received	2015-04-04 13:26
Peer-Review Started	2015-04-04 17:56
To Make the First Decision	2015-06-02 15:24
Return for Revision	2015-06-07 17:56
Revised	2015-06-17 18:34
Second Decision	2015-07-27 20:16
Accepted by Journal Editor-in-Chief	2015-07-27 21:21
Accepted by Company Editor-in-Chief	2015-09-02 09:03
Articles in Press	2015-09-02 09:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-10 14:56
Publish the Manuscript Online	2015-10-14 12:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	What’s new in hepatitis C virus infections in children?
Manuscript Source	Invited Manuscript
All Author List	Malgorzata Pawlowska, Krzysztof Domagalski, Anna Pniewska, Beata Smok, Waldemar Halota and Andrzej Tretyn
Funding Agency and Grant Number
Corresponding Author	Malgorzata Pawlowska, MD, PhD, Professor, Department of Paediatric Infectious Diseases and Haepatology, Faculty of Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Floriana 12, 85-030 Bydgoszcz, Poland. mpawlowska@cm.umk.pl
Key Words	Hepatitis C virus; Infection in children; Single nucleotide polymorphisms; Epidemiology; Biomarkers of liver injury; Vertical infection
Core Tip	Vertical transmission (VT) is the most common cause of hepatitis C virus (HCV) infection in children. It is important to introduce routine HCV screening tests in pregnant women. Some hopes for VTC prophylaxis are associated with directly acting antiviral agents. IL-28B single nucleotide polymorphisms may help to identify children with spontaneous clearance and with good treatment prognosis. Developing non-invasive tests that can predict liver fibrosis in children is important. New biomarkers of liver injury (ITIH4, C4a, arginase 1) have been shown to reflect liver fibrosis and steatosis. The differences in liver injury between children and adults create new perspectives of action to reduce liver disease progression in children.
Publish Date	2015-10-14 12:06
Citation	Pawlowska M, Domagalski K, Pniewska A, Smok B, Halota W, Tretyn A. What’s new in hepatitis C virus infections in children? World J Gastroenterol 2015; 21(38): 10783-10789
URL	http://www.wjgnet.com/1007-9327/full/v21/i38/10783.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i38.10783

Full Article (PDF)	WJG-21-10783.pdf
Full Article (Word)	WJG-21-10783.doc
Manuscript File	18049-Review.doc
Answering Reviewers	18049-Answering reviewers._pdf
Audio Core Tip	18049-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18049-Conflict-of-interest statement.pdf
Copyright License Agreement	18049-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18049-Language certificate.pdf
Peer-review Report	18049-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18049-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18049-Scientific misconduct check.pdf
Scientific Editor Work List	18049-Scientific editor work list.pdf