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9/28/2015 6:06:00 PM | Browse: 360 | Download: 574
Publication Name World Journal of Gastroenterology
Manuscript ID 18095
Country of Manuscript Source Italy
Received
2015-04-07 09:05
Peer-Review Started
2015-04-07 15:23
To Make the First Decision
2015-04-23 13:18
Return for Revision
2015-05-01 14:07
Revised
2015-06-15 00:00
Second Decision
2015-08-20 20:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-08-25 18:46
Articles in Press
2015-08-25 18:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-09-05 22:52
Typeset the Manuscript
2015-09-10 18:38
Publish the Manuscript Online
2015-09-28 18:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Topic Highlights
Article Title Targeting mast cells in gastric cancer with special reference to bone metastases
Manuscript Source Invited Manuscript
All Author List Christian Leporini, Michele Ammendola, Ilaria Marech, Giuseppe Sammarco, Rosario Sacco, Cosmo Damiano Gadaleta, Caroline Oakley, Emilio Russo, Giovambattista De Sarro and Girolamo Ranieri
Funding Agency and Grant Number
Corresponding author Michele Ammendola, MD, Department of Medical and Surgery Sciences, Clinical Surgery Unit, University of Catanzaro “Magna Graecia” Medical School, Viale Europa - Germaneto, 88100 Catanzaro, Italy. michele.ammendola@libero.it
Keywords Bone metastases; Gastric cancer; Receptor activator of nuclear factor-B; Angiogenesis; Osteoclastic bone resorption; Tryptase inhibitors; c-Kit receptor tyrosine kinase inhibitors; Anti-angiogenic therapy
Core Tip The activation of the stem cell factor/c-Kit receptor (c-KitR) pathway in mast cells (MCs), and tryptase release upon MCs degranulation have a pivotal role in tumor angiogenesis in several human malignancies. MCs positive to tryptase (MCPT) have been implicated in primary gastric cancer (GC) an?giogenesis. Our preliminary findings indicated that bone metastasis angiogenesis from GC is also supported by infiltrating MCPTs. Overall, the evidence provides a rationale to evaluate c-KitR inhibitors that block MCs degranulation, or tryptase inhibitors that inhibit tryptase and/or the Proteinase-Activated Receptor-2 pathway, in clinical trials for bone metastasis GC patients.
Publish Date 2015-09-28 18:06
Citation Leporini C, Ammendola M, Marech I, Sammarco G, Sacco R, Gadaleta CD, Oakley C, Russo E, De Sarro G, Ranieri G. Targeting mast cells in gastric cancer with special reference to bone metastases. World J Gastroenterol 2015; 21(37): 10493-10501
Url http://www.wjgnet.com/1007-9327/full/v21/i37/10493.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i37.10493
Full Article (PDF) WJG-21-10493.pdf
Full Article (Word) WJG-21-10493.doc
Manuscript File 18095-Review.doc
Answering Reviewers 18095-Answering reviewers.pdf
Audio Core Tip 18095-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 18095-Conflict-of-interest statement.pdf
Copyright License Agreement 18095-Copyright assignment.pdf
Peer-review Report 18095-Peer-review(s).pdf
Scientific Misconduct Check 18095-Scientific misconduct check.pdf
Scientific Editor Work List 18095-Scientific editor work list.pdf