Publication Name	World Journal of Gastroenterology
Manuscript ID	18095
Country	Italy

Received	2015-04-07 09:05
Peer-Review Started	2015-04-07 15:23
To Make the First Decision	2015-04-23 13:18
Return for Revision	2015-05-01 14:07
Revised	2015-06-15 00:00
Second Decision	2015-08-20 20:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-08-25 18:46
Articles in Press	2015-08-25 18:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-05 22:52
Typeset the Manuscript	2015-09-10 18:38
Publish the Manuscript Online	2015-09-28 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Targeting mast cells in gastric cancer with special reference to bone metastases
Manuscript Source	Invited Manuscript
All Author List	Christian Leporini, Michele Ammendola, Ilaria Marech, Giuseppe Sammarco, Rosario Sacco, Cosmo Damiano Gadaleta, Caroline Oakley, Emilio Russo, Giovambattista De Sarro and Girolamo Ranieri
Funding Agency and Grant Number
Corresponding Author	Michele Ammendola, MD, Department of Medical and Surgery Sciences, Clinical Surgery Unit, University of Catanzaro “Magna Graecia” Medical School, Viale Europa - Germaneto, 88100 Catanzaro, Italy. michele.ammendola@libero.it
Key Words	Bone metastases; Gastric cancer; Receptor activator of nuclear factor-B; Angiogenesis; Osteoclastic bone resorption; Tryptase inhibitors; c-Kit receptor tyrosine kinase inhibitors; Anti-angiogenic therapy
Core Tip	The activation of the stem cell factor/c-Kit receptor (c-KitR) pathway in mast cells (MCs), and tryptase release upon MCs degranulation have a pivotal role in tumor angiogenesis in several human malignancies. MCs positive to tryptase (MCPT) have been implicated in primary gastric cancer (GC) an?giogenesis. Our preliminary findings indicated that bone metastasis angiogenesis from GC is also supported by infiltrating MCPTs. Overall, the evidence provides a rationale to evaluate c-KitR inhibitors that block MCs degranulation, or tryptase inhibitors that inhibit tryptase and/or the Proteinase-Activated Receptor-2 pathway, in clinical trials for bone metastasis GC patients.
Publish Date	2015-09-28 18:06
Citation	Leporini C, Ammendola M, Marech I, Sammarco G, Sacco R, Gadaleta CD, Oakley C, Russo E, De Sarro G, Ranieri G. Targeting mast cells in gastric cancer with special reference to bone metastases. World J Gastroenterol 2015; 21(37): 10493-10501
URL	http://www.wjgnet.com/1007-9327/full/v21/i37/10493.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i37.10493

Full Article (PDF)	WJG-21-10493.pdf
Full Article (Word)	WJG-21-10493.doc
Manuscript File	18095-Review.doc
Answering Reviewers	18095-Answering reviewers.pdf
Audio Core Tip	18095-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18095-Conflict-of-interest statement.pdf
Copyright License Agreement	18095-Copyright assignment.pdf
Peer-review Report	18095-Peer-review(s).pdf
Scientific Misconduct Check	18095-Scientific misconduct check.pdf
Scientific Editor Work List	18095-Scientific editor work list.pdf