Publication Name	World Journal of Gastroenterology
Manuscript ID	18128
Country	Japan

Received	2015-04-08 08:30
Peer-Review Started	2015-04-08 17:09
To Make the First Decision	2015-04-23 14:41
Return for Revision	2015-05-01 13:37
Revised	2015-05-14 17:44
Second Decision	2015-06-03 08:16
Accepted by Journal Editor-in-Chief	2015-06-03 08:37
Accepted by Executive Editor-in-Chief	2015-06-10 17:44
Articles in Press	2015-06-10 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-25 10:24
Publish the Manuscript Online	2015-07-08 12:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Geographic differences in low-dose aspirin-associated gastroduodenal mucosal injury
Manuscript Source	Invited Manuscript
All Author List	Katsunori Iijima and Tooru Shimosegawa
Funding Agency and Grant Number
Corresponding Author	Katsunori Iijima, MD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo-machi, Aobaku, Sendai 980-8574, Japan. kiijima@med.tohoku.ac.jp
Key Words	Helicobacter pylori; Low-dose aspirin; Gastric acid secretion; Gastroduodenal ulcers; Geographic variation
Core Tip	There have been conflicting results about the potential interaction between these low-dose aspirin (LDA) use and Helicobacter pylori (H. pylori) infection on the gastroduodenal ulcers and the geographic areas involved. H. pylori infection could have a synergistic or antagonistic interaction with LDA use in adverse gastroduodenal events depending on gastric acid secretion. Large geographic differences in the net effect of H. pylori infection on gastric acid secretion could be at least partly responsible for the geographically distinct interaction between LDA use and H. pylori infection on adverse gastroduodenal lesions.
Publish Date	2015-07-08 12:01
Citation	Iijima K, Shimosegawa T. Geographic differences in low-dose aspirin-associated gastroduodenal mucosal injury. World J Gastroenterol 2015; 21(25): 7709-7717
URL	http://www.wjgnet.com/1007-9327/full/v21/i25/7709.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i25.7709

Full Article (PDF)	WJG-21-7709.pdf
Full Article (Word)	WJG-21-7709.doc
Manuscript File	18128-Review.docx
Answering Reviewers	18128-Answering reviewers.pdf
Audio Core Tip	18128-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18128-Conflict-of-interest statement.pdf
Copyright License Agreement	18128-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18128-Language certificate.pdf
Peer-review Report	18128-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18128-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18128-Scientific misconduct check.pdf
Scientific Editor Work List	18128-Scientific editor work list.pdf