Publication Name	World Journal of Hepatology
Manuscript ID	18129
Country	Japan

Received	2015-04-08 08:27
Peer-Review Started	2015-04-09 20:08
To Make the First Decision	2015-05-14 16:44
Return for Revision	2015-05-19 09:15
Revised	2015-05-28 16:42
Second Decision	2015-06-24 08:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-02 16:26
Articles in Press	2015-07-02 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-10 14:58
Publish the Manuscript Online	2015-08-21 13:37

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Hayato Nakagawa
Funding Agency and Grant Number	Funding Agency Grant Number Japanese Society of Gastroenterology Tokyo Society of Medical Sciences Kanae Foundation for the Promotion of Medical Science
Corresponding Author	Hayato Nakagawa, MD, PhD, Depart­ment of Gastroenterology, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. hanakagawa-tky@umin.ac.jp
Key Words	Obesity; Metabolic syndrome; Nonalcoholic steatohepatitis; Hepatocellular carcinoma; Mouse model
Core Tip	Obesity is a recognized risk factor for the development of hepatocellular carcinoma (HCC) and nonalcoholic steatohepatitis (NASH), which in turn can trigger hepatocarcinogenesis. Once, no appropriate mouse model allowed exploration of the associations among obesity, NASH, and HCC, but several innovative mouse models have become established in recent years. These models have afforded new insights into the mechanisms of disease and have suggested new therapeutic strategies. Therefore, this paper reviews mouse models of obesity- and NASH-associated HCC, focusing on recent advances and clinical relevance thereof.
Publish Date	2015-08-21 13:37
Citation	Nakagawa H. Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis. World J Hepatol 2015; 7(17): 2110-2118
URL	http://www.wjgnet.com/1948-5182/full/v7/i17/2110.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i17.2110

Full Article (PDF)	WJH-7-2110.pdf
Full Article (Word)	WJH-7-2110.doc
Manuscript File	18129-Review.doc
Answering Reviewers	18129-Answering reviewers.pdf
Audio Core Tip	18129-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18129-Conflict-of-interest statement.pdf
Copyright License Agreement	18129-Copyright assignment.pdf
Peer-review Report	18129-Peer-review(s).pdf
Scientific Misconduct Check	18129-Scientific misconduct check.pdf
Scientific Editor Work List	18129-Scientific editor work list.pdf