Publication Name	World Journal of Gastroenterology
Manuscript ID	18136
Country	Sweden

Received	2015-04-08 14:02
Peer-Review Started	2015-04-09 08:08
To Make the First Decision	2015-06-19 17:49
Return for Revision	2015-06-20 13:25
Revised	2015-08-27 03:14
Second Decision	2015-09-12 21:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-14 11:03
Articles in Press	2015-09-14 11:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-25 16:37
Publish the Manuscript Online	2015-12-15 12:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours
Manuscript Source	Unsolicited Manuscript
All Author List	Apostolos V Tsolakis, Lars Grimelius, Göran Granerus, Mats Stridsberg, Sture E Falkmer and Eva T Janson
Funding Agency and Grant Number	Funding Agency Grant Number Selander Foundation and the Foundation for Clinical Cancer Research in Jönköping
Corresponding Author	Apostolos V Tsolakis, MD, PhD, Section of Endocrine Oncology, Department of Medical Sciences, Uppsala University, SE-75185 Uppsala, Sweden. apobtsol@hotmail.com
Key Words	Enterochromaffin-like cells; High performance liquid chromatography; Gastric neuroendocrine tumours; Histidine decarboxylase; Immunohistochemistry; Urinary excretion of the main histamine metabolite methylimidazoleacetic acid; Vesicular monoamine transporter 2
Core Tip	It is suggested that only a fraction of vesicular monoamine transporter 2 (VMAT-2) immunoreactive neuroendocrine cells in human oxyntic mucosa co-express histidine decarboxylase (HDC), and vice versa, suggesting that the enterochromaffin-like (ECL) cells may not represent a homogeneous cell population when examined for HDC immunoreactivity. Co-expression of VMAT-2 and HDC might be important for giving rise to increased histamine production in patients with ECL cell neuroendocrine tumours. Furthermore, an increase of urinary excretion of the main histamine metabolite methylimidazoleacetic acid was not always associated with hormonal symptoms. This result could be attributed to the rate of histamine release. A sudden rapid release will cause a flush, whereas a slower release will not.
Publish Date	2015-12-15 12:22
Citation	Tsolakis AV, Grimelius L, Granerus G, Stridsberg M, Falkmer SE, Janson ET. Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours. World J Gastroenterol 2015; 21(47): 13240-13249
URL	http://www.wjgnet.com/1007-9327/full/v21/i47/13240.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i47.13240

Full Article (PDF)	WJG-21-13240.pdf
Full Article (Word)	WJG-21-13240.doc
Manuscript File	18136-Review.doc
Answering Reviewers	18136-Answering reviewers.pdf
Audio Core Tip	18136-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	18136-Conflict-of-interest statement.pdf
Copyright License Agreement	18136-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	18136-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	18136-Language certificate.pdf
Peer-review Report	18136-Peer-review(s).pdf
Scientific Misconduct Check	18136-Scientific misconduct check.pdf
Scientific Editor Work List	18136-Scientific editor work list.pdf