| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Qin Liao, Ya-Lei Qi, Lin Wang, Xiao-Ming Dong, Tao Xu, Chao-Dong Ding, Rui Liu, Wei-Cheng Liang, Li-Ting Lu, He Li, Wen-Feng Li, Guang-Bin Luo and Xin-Cheng Lu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81101472 |
| National Natural Science Foundation of China |
81472556 (to Liao W) |
| National Natural Science Foundation of China |
81372490 (to Lu X) |
| Zhejiang Provincial Natural Science Foundation |
LZ14H160003 (to Lu X) |
| Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents |
to Lu X |
| National Basic Research Program of China (973 Project) |
2011CB504603 |
| Wenzhou Municipal Science and Technology Bureau Foundation |
Y20110090 (to Li H) |
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| Corresponding Author |
Xin-cheng Lu, Professor, School of Basic Medical Science, Wenzhou Medical University, Chashan Campus, Chashan University Town, Wenzhou 325027, Zhejiang Province, China. xinchenglu@yahoo.com
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| Key Words |
Recql5; Liver injury; Apoptosis; Oxidative stress; CYP450 |
| Core Tip |
Wild type and Recql5-deficient mice were intraperitoneally injected with lipopolysaccharide and D-galactosamine (LPS/D-Gal). The aim of the study was to explore the effects of Recql5 deficiency on LPS/D-Gal-induced liver injury. Our findings reveal that Recql5 protects against liver injury via inhibition of hepatocyte apoptosis and oxidative stress and regulation of hepatic CYP450 expression levels.
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| Publish Date |
2015-09-28 11:42 |
| Citation |
Liao WQ, Qi YL, Wang L, Dong XM, Xu T, Ding CD, Liu R, Liang WC, Lu LT, Li H, Li WF, Luo GB, Lu XC. Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice. World J Gastroenterol 2015; 21(36): 10375-10384 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i36/10375.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i36.10375 |
