Publication Name	World Journal of Clinical Oncology
Manuscript ID	18183
Country	India

Received	2015-04-10 08:20
Peer-Review Started	2015-04-11 23:29
To Make the First Decision	2015-06-03 14:40
Return for Revision	2015-06-04 17:37
Revised	2015-08-04 15:01
Second Decision	2015-08-27 11:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-08 15:11
Articles in Press	2015-09-08 15:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-27 14:00
Publish the Manuscript Online	2015-12-09 18:37

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Review
Article Title	Dynamic role of myofibroblasts in oral lesions
Manuscript Source	Unsolicited Manuscript
All Author List	Neeta Bagul, Anjali Ganjre­, SN Goryawala, Rahul Kathariya and Shrikant Dusane
Funding Agency and Grant Number
Corresponding Author	Dr. Rahul Kathariya, MDS, PhD, Department of Periodontology and Oral Implantology, Dr. D.Y Patil Dental College and Hospital, Dr. D. Y Patil Vidyapeeth, Sant Tukaram Nagar, Pimpri, Pune 411018, India. rkathariya@gmail.com
Key Words	Myofibroblasts; Neoplasm; Fibroblasts; Precancerous lesions; Precancerous conditions; Carcinoma-associated fibroblasts
Core Tip	Myofibroblast (MFs) are spindle-shaped cells consisting α-smooth muscle actin myofilament. They have a multicellular origin. MFs of the oral cavity have more contractile ability than dermal fibroblasts in physiologic wound healing. Recently, carcinoma-associated fibroblasts (CAFs) have received considerable attention because of their role in carcinogenesis. Mainly, transforming growth factor-β released from oral cancer cells is responsible for transforming fibroblasts into CAFs, which leads to tumour progression. However, the role of MFs in oral leukoplakia and oral submucous fibrosis is not completely understood. Understanding the implications of therapeutic approaches for the transdifferentiation of fibroblasts into MFs at different stages of carcinogenesis will facilitate in developing a treatment plan.
Publish Date	2015-12-09 18:37
Citation	Bagul N, Ganjre A­, Goryawala SN, Kathariya R, Dusane S. Dynamic role of myofibroblasts in oral lesions. World J Clin Oncol 2015; 6(6): 264-271
URL	http://www.wjgnet.com/2218-4333/full/v6/i6/264.htm
DOI	http://dx.doi.org/10.5306/wjco.v6.i6.264

Full Article (PDF)	WJCO-6-264.pdf
Full Article (Word)	WJCO-6-264.doc
Manuscript File	18183-Review.docx
Answering Reviewers	18183-Answering reviewers.pdf
Audio Core Tip	18183-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18183-Conflict-of-interest statement.pdf
Copyright License Agreement	18183-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18183-Language certificate.pdf
Peer-review Report	18183-Peer-review(s).pdf
Scientific Misconduct Check	18183-Scientific misconduct check.pdf
Scientific Editor Work List	18183-Scientific editor work list.pdf