Publication Name	World Journal of Gastroenterology
Manuscript ID	18193
Country	Greece

Received	2015-04-11 10:58
Peer-Review Started	2015-04-11 12:53
To Make the First Decision	2015-05-18 13:11
Return for Revision	2015-05-20 19:13
Revised	2015-07-01 05:24
Second Decision	2015-09-28 16:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 10:09
Articles in Press	2015-09-30 10:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-10-27 04:57
Typeset the Manuscript	2015-12-04 14:55
Publish the Manuscript Online	2016-01-06 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Allergy
Manuscript Type	Topic Highlights
Article Title	Helicobacter pylori and colorectal neoplasia: Is there a causal link?
Manuscript Source	Invited Manuscript
All Author List	Vasilios Papastergiou, Stylianos Karatapanis and Sotirios D Georgopoulos
Funding Agency and Grant Number
Corresponding Author	Sotirios D Georgopoulos, MD, FEBGH, AGAF, Director, Division of Internal Medicine, Department of Gastroenterology, Athens Medical, Paleo Faliron General Hospital, Areos 36, Paleo Faliron, 17562 Athens, Greece. georgpap@ath.forthnet.gr
Key Words	Helicobacter pylori; Colorectal cancer; Polyp; Adenoma; Gastrin
Core Tip	Helicobacter pylori (H. pylori) is a well-recognized gastric carcinogen; however, a causal relationship with colorectal neoplasia remains uncertain. Data from case-control and cross-sectional studies, as well as several meta-analyses, have indicated a significant, although modest, statistical association between infection with H. pylori/H. pylori-related gastritis and the development of colorectal adenomas or cancer. Potential tumorigenic actions of H. pylori to colorectal mucosa include induction of inflammatory responses, alteration of gut microflora and release of toxins and/or hormonal mediators.
Publish Date	2016-01-06 16:13
Citation	Papastergiou V, Karatapanis S, Georgopoulos SD. Helicobacter pylori and colorectal neoplasia: Is there a causal link? World J Gastroenterol 2016; 22(2): 649-658
URL	http://www.wjgnet.com/1007-9327/full/v22/i2/649.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i2.649

Full Article (PDF)	WJG-22-649.pdf
Full Article (Word)	WJG-22-649.doc
Manuscript File	18193-Review.docx
Answering Reviewers	18193-Answering reviewers.pdf
Audio Core Tip	18193-Audio core tip.mp3
Copyright License Agreement	18193-Copyright Assignment.pdf
Peer-review Report	18193-Peer-review(s).pdf
Scientific Misconduct Check	18193-Scientific misconduct check.pdf
Scientific Editor Work List	18193-Scientific editor work list.pdf