Publication Name	World Journal of Gastroenterology
Manuscript ID	18206
Country	China

Received	2015-04-12 12:28
Peer-Review Started	2015-04-13 08:10
First Decision by Editorial Office Director
Return for Revision	2015-06-26 19:30
Revised	2015-07-27 23:46
Publication Fee Transferred
Second Decision by Editor	2015-10-23 16:33
Second Decision by Editor-in-Chief	2015-10-26 07:21
Final Decision by Editorial Office Director	2015-12-01 09:22
Articles in Press	2015-12-01 09:22
Edit the Manuscript by Language Editor	2015-12-29 03:57
Typeset the Manuscript	2016-01-15 11:03
Publish the Manuscript Online	2016-01-23 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Hepatocellular carcinoma and hepatitis B surface protein
Manuscript Source	Invited Manuscript
All Author List	Yong-Wei Li, Feng-Cai Yang, Hui-Qiong Lu and Jiong-Shan Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Project of Guangdong Province 2014A020212073
Corresponding Author	Dr. Yong-Wei Li, Department of Traditional Chinese Medicine, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. liyongwei22@163.com
Key Words	Hepatitis B surface protein; Hepatocellular carcinoma; PreS/S mutants; Endoplasmic reticulum stress; “Ground Glass” hepatocytes
Core Tip	The tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma (HCC) has been widely studied. The preS/S mutants are considered “precursor lesions” of HCC. Different preS/S mutants induce various mechanisms of tumorigenesis, such as transactivation and an inflammatory response. The preS2 mutants and type Ⅱ “Ground Glass” hepatocytes represent novel biomarkers of HCC. The preS mutants may induce the unfolded protein response and endoplasmic reticulum stress-dependent and stress-independent pathways. Treatments to inhibit hepatitis B surface antigen (HBsAg) and damage secondary to HBsAg or the preS/S mutants include antivirals and antioxidants. Methods for the prevention and treatment of HCC should be comprehensive.
Publish Date	2016-01-23 17:08
Citation	Li YW, Yang FC, Lu HQ, Zhang JS. Hepatocellular carcinoma and hepatitis B surface protein. World J Gastroenterol 2016; 22(6): 1943-1952
URL	http://www.wjgnet.com/1007-9327/full/v22/i6/1943.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i6.1943

Full Article (PDF)	WJG-22-1943.pdf
Full Article (Word)	WJG-22-1943.doc
Manuscript File	18206-Review.doc
Answering Reviewers	18206-Answering reviewers.pdf
Audio Core Tip	18206-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18206-Conflict-of-interest statement.pdf
Copyright License Agreement	18206-Copyright assignment.pdf
Peer-review Report	18206-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18206-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18206-Scientific misconduct check.pdf
Scientific Editor Work List	18206-Scientific editor work list.pdf