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9/20/2015 9:45:00 PM | Browse: 534 | Download: 762
Publication Name World Journal of Cardiology
Manuscript ID 18233
Country/Territory Germany
Received
2015-04-13 08:40
Peer-Review Started
2015-04-18 17:22
To Make the First Decision
2015-05-13 19:44
Return for Revision
2015-05-19 14:01
Revised
2015-05-29 03:43
Second Decision
2015-07-24 11:38
Accepted by Journal Editor-in-Chief
2015-07-24 15:42
Accepted by Company Editor-in-Chief
2015-08-03 15:52
Articles in Press
2015-08-03 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-09-09 20:56
Publish the Manuscript Online
2015-09-20 21:45
ISSN 1949-8462 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac and Cardiovascular Systems
Manuscript Type Minireviews
Article Title Challenging aspects of treatment strategies in heart failure with preserved ejection fraction: “Why did recent clinical trials fail?”
Manuscript Source Invited Manuscript
All Author List Peter Moritz Becher, Nina Fluschnik, Stefan Blankenberg and Dirk Westermann
Funding Agency and Grant Number
Corresponding author Peter Moritz Becher, MD, Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. m.becher@uke.de
Keywords Diastolic dysfunction; Preserved ejection fraction; Co-morbidities; Clinical trials
Core Tip Heart failure (HF) has preserved left ventricular ejection fraction (HFpEF) accounts for approximately 50% of all patients diagnosed with HF, with similary poor outcomes. To date, only the prevention of HFpEF by treating the cardiovascular risk factors (coronary artery disease, atrial fibrillation, hypertension, diabetes, and obesity) has been shown to be efficient. This observation suggests that investigators in future trials should specify the indication of hospitalization for HF and may request to verify the details of patients’ admissions. We provide an outline and interpretation of recent clinical trials that failed to improve outcome and survival in patients with HF with preserved ejection fraction.
Publish Date 2015-09-20 21:45
Citation Becher PM, Fluschnik N, Blankenberg S, Westermann D. Challenging aspects of treatment strategies in heart failure with preserved ejection fraction: “Why did recent clinical trials fail?” World J Cardiol 2015; 7(9): 544-554
Url http://www.wjgnet.com/1949-8462/full/v7/i9/544.htm
DOI http://dx.doi.org/10.4330/wjc.v7.i9.544
Full Article (PDF) WJC-7-544.pdf
Full Article (Word) WJC-7-544.doc
Manuscript File 18233-Review.doc
Answering Reviewers 18233-Answering reviewers.pdf
Audio Core Tip 18233-Audio core tip.wav
Conflict-of-Interest Disclosure Form 18233-Conflict-of-interest statement.pdf
Copyright License Agreement 18233-Copyright assignment.pdf
Peer-review Report 18233-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 18233-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 18233-Scientific misconduct check.pdf
Scientific Editor Work List 18233-Scientific editor work list.pdf