Publication Name	World Journal of Gastroenterology
Manuscript ID	18255
Country	United Kingdom

Received	2015-04-14 09:58
Peer-Review Started	2015-04-15 18:44
To Make the First Decision	2015-05-18 12:57
Return for Revision	2015-05-20 09:03
Revised	2015-06-03 16:55
Second Decision	2015-09-28 16:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 10:10
Articles in Press	2015-09-30 10:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-20 16:55
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Immune dysfunction in acute alcoholic hepatitis
Manuscript Source	Invited Manuscript
All Author List	Ashwin D Dhanda and Peter L Collins
Funding Agency and Grant Number
Corresponding Author	Ashwin D Dhanda, MRCP, PhD, NIHR Academic Clinical Lecturer in Hepatology, Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, John Bull Building, Research Way, Devon, PL6 8BU Plymouth, United Kingdom. ashwin.dhanda@plymouth.ac.uk
Key Words	Alcoholic hepatitis; Alcoholic liver disease; Toll-like receptors; Gut dysbiosis; T cell exhaustion
Core Tip	Acute alcoholic hepatitis (AAH) has high short-term mortality and is challenging to treat with only glucocorticoids demonstrating proven survival benefit. Development of other effective treatment requires a clear understanding of the mechanisms of immune dysfunction in AAH. Here, we review recent progress in the field and identify areas in need of further research; particularly the role of gut dysbiosis in allowing presentation of pathogen associated molecular patterns to innate receptors on myeloid cells and the subsequent recruitment of immune cell subsets. Recent data demonstrating that T cells have an exhausted phenotype and result in impaired antimicrobial defence is also discussed.
Publish Date	2015-11-11 13:34
Citation	Dhanda AD, Collins PL. Immune dysfunction in acute alcoholic hepatitis. World J Gastroenterol 2015; 21(42): 11904-11913
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/11904.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.11904

Full Article (PDF)	WJG-21-11904.pdf
Full Article (Word)	WJG-21-11904.doc
Manuscript File	18255-Review.docx
Answering Reviewers	18255-Answering reviewers.pdf
Audio Core Tip	18255-Audio core tip.mp3
Copyright License Agreement	18255-Copyright assignment.pdf
Peer-review Report	18255-Peer-review(s).pdf
Scientific Misconduct Check	18255-Scientific misconduct check.pdf
Scientific Editor Work List	18255-Scientific editor work list.pdf