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Articles Published Processes
8/8/2015 2:17:00 PM | Browse: 1009 | Download: 1605
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Received |
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2015-04-14 09:39 |
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Peer-Review Started |
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2015-04-14 20:29 |
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To Make the First Decision |
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2015-05-13 19:42 |
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Return for Revision |
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2015-05-19 14:12 |
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Revised |
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2015-05-26 14:23 |
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Second Decision |
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2015-06-12 16:36 |
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Accepted by Journal Editor-in-Chief |
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2015-06-12 17:04 |
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Accepted by Executive Editor-in-Chief |
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2015-06-19 18:07 |
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Articles in Press |
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2015-06-19 18:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-07-24 10:33 |
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Publish the Manuscript Online |
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2015-08-08 14:17 |
ISSN |
1948-5182 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Editorial |
Article Title |
Autophagy: A new therapeutic target for liver fibrosis
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Manuscript Source |
Invited Manuscript |
All Author List |
Yu-Qing Mao and Xiao-Ming Fan |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Research grant from key clinical disciplines construction of Shanghai Municipality, China |
ZK2012B20 |
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Corresponding Author |
Xiao-Ming Fan, MD, PhD, Professor, Department of Gastroenterology, Jinshan Hospital of Fudan University, 1508 Longhang road, Shanghai 201508,
China. xiaomingfan57@sina.com
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Key Words |
Autophagy; Liver fibrosis; Hepatic stellate cells; Antifibrotic target |
Core Tip |
Autophagy plays dual roles in hepatic fibrosis. On the one hand, it attenuates fibrosis by reducing hepatic injury via inhibiting inflammatory reaction and maintaining cellular homeostasis. On the other hand, it fuels activation of hepatic stellate cells (HSCs) by lipophagy and induces type?Ⅰ?collagen synthesis. More studies using Atg selective knockdown mice or primary HSCs derived from Atg-deleted mice are needed. Selective inhibition of autophagy in HSCs is an attractive antifibrotic strategy.
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Publish Date |
2015-08-08 14:17 |
Citation |
Mao YQ, Fan XM. Autophagy: A new therapeutic target for liver fibrosis. World J Hepatol 2015; 7(16): 1982-1986 |
URL |
http://www.wjgnet.com/1948-5182/full/v7/i16/1982.htm |
DOI |
http://dx.doi.org/10.4254/wjh.v7.i16.1982 |
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