Publication Name	World Journal of Hepatology
Manuscript ID	18263
Country	Greece

Received	2015-04-14 09:36
Peer-Review Started	2015-04-24 11:37
First Decision by Editorial Office Director
Return for Revision	2015-05-19 11:15
Revised	2015-05-29 19:39
Publication Fee Transferred
Second Decision by Editor	2015-06-24 08:28
Second Decision by Editor-in-Chief	2015-06-27 13:14
Final Decision by Editorial Office Director	2015-07-02 16:27
Articles in Press	2015-07-02 16:28
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-07 09:58
Publish the Manuscript Online	2015-07-24 19:52

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Gary L Norman, Nikolaos K Gatselis, Zakera Shums, Christos Liaskos, Dimitrios P Bogdanos, George K Koukoulis and George N Dalekos
Funding Agency and Grant Number
Corresponding Author	George N Dalekos, MD, PhD, Professor, Head, Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Biopolis, 41110 Larissa, Greece. dalekos@med.uth.gr
Key Words	Hepatic fibrosis; Hepatocellular carcinoma; Viral hepatitis; Enzyme-linked immunosorbent assay; Biomarker; Cirrhosis
Core Tip	We report our first results regarding the utility of serum cartilage oligomeric matrix protein (COMP), an antigen over-expressed in developing liver, as a novel non-invasive marker of liver fibrosis and risk of progression to hepatocellular carcinoma (HCC). HCC is the third leading cause of cancer deaths worldwide, therefore non-invasive tests of fibrosis, as well as tests that can predict which patients are at high risk to develop HCC are needed. Our results suggest that COMP levels are associated with cirrhosis and a worse prognosis, thus serum COMP may assist clinicians as a non-invasive biomarker for risk assessment in surveillance programs.
Publish Date	2015-07-24 19:52
Citation	Norman GL, Gatselis NK, Shums Z, Liaskos C, Bogdanos DP, Koukoulis GK, Dalekos GN. Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma. World J Hepatol 2015; 7(14): 1875-1883
URL	http://www.wjgnet.com/1948-5182/full/v7/i14/1875.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i14.1875

Full Article (PDF)	WJH-7-1875.pdf
Full Article (Word)	WJH-7-1875.doc