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Articles Published Processes
7/24/2015 7:52:00 PM | Browse: 1124 | Download: 2037
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Received |
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2015-04-14 09:36 |
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Peer-Review Started |
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2015-04-24 11:37 |
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To Make the First Decision |
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2015-05-13 19:27 |
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Return for Revision |
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2015-05-19 11:15 |
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Revised |
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2015-05-29 19:39 |
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Second Decision |
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2015-06-24 08:28 |
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Accepted by Journal Editor-in-Chief |
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2015-06-27 13:14 |
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Accepted by Company Editor-in-Chief |
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2015-07-02 16:27 |
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Articles in Press |
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2015-07-02 16:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-07-07 09:58 |
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Publish the Manuscript Online |
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2015-07-24 19:52 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gary L Norman, Nikolaos K Gatselis, Zakera Shums, Christos Liaskos, Dimitrios P Bogdanos, George K Koukoulis and George N Dalekos |
| Funding Agency and Grant Number |
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| Corresponding Author |
George N Dalekos, MD, PhD, Professor, Head, Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Biopolis, 41110 Larissa, Greece. dalekos@med.uth.gr
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| Key Words |
Hepatic fibrosis; Hepatocellular carcinoma; Viral hepatitis; Enzyme-linked immunosorbent assay; Biomarker; Cirrhosis |
| Core Tip |
We report our first results regarding the utility of serum cartilage oligomeric matrix protein (COMP), an antigen over-expressed in developing liver, as a novel non-invasive marker of liver fibrosis and risk of progression to hepatocellular carcinoma (HCC). HCC is the third leading cause of cancer deaths worldwide, therefore non-invasive tests of fibrosis, as well as tests that can predict which patients are at high risk to develop HCC are needed. Our results suggest that COMP levels are associated with cirrhosis and a worse prognosis, thus serum COMP may assist clinicians as a non-invasive biomarker for risk assessment in surveillance programs.
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| Publish Date |
2015-07-24 19:52 |
| Citation |
Norman GL, Gatselis NK, Shums Z, Liaskos C, Bogdanos DP, Koukoulis GK, Dalekos GN. Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma. World J Hepatol 2015; 7(14): 1875-1883 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i14/1875.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i14.1875 |
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