Publication Name	World Journal of Biological Chemistry
Manuscript ID	18283
Country	France

Received	2015-04-14 17:45
Peer-Review Started	2015-04-14 19:57
To Make the First Decision	2015-05-13 19:41
Return for Revision	2015-05-19 14:24
Revised	2015-05-27 15:50
Second Decision	2015-09-28 14:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-10-13 17:06
Articles in Press	2015-10-13 17:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:23
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemical Research Methods
Manuscript Type	Minireviews
Article Title	Cyclin A2: At the crossroads of cell cycle and cell invasion
Manuscript Source	Invited Manuscript
All Author List	Abdelhalim Loukil, Caroline T Cheung, Nawal Bendris, Bénédicte Lemmers, Marion Peter and Jean Marie Blanchard
Funding Agency and Grant Number	Funding Agency Grant Number Agence Nationale de la Recherche, Fondation ARC pour la Recherche sur le Cancer, and Gefluc 08-BLAN-0037-02 CNRS/Région Languedoc-Roussillon and Fondation pour la Recherche Médicale to Loukil A French Ministry of Education and Research and Fondation pour la Recherche Médicale to Bendris N Canadian Institutes of Health Research, La Ligue Contre le Cancer and the Fondation de France to Cheung CT
Corresponding Author	Jean Marie Blanchard, PhD, Institut de Génétique Moléculaire de Montpellier, CNRS, 1919 route de Mende, 34293 Montpellier, France. jean-marie.blanchard@igmm.cnrs.fr
Key Words	Cyclin; Mitosis; Mesenchymal transition; Metastasis; Autophagy; RhoA; Phospholipase C
Core Tip	Cyclin A2, as an essential regulator of the cell division cycle, is commonly associated to dividing cells and, like Ki67, is usually taken as a marker of cell proliferation. However, the level of this cyclin does not always correlate with the aggressiveness of the tumor, more particularly with respect to its invasiveness. Surprisingly, recent data suggest that it plays with RhoA also a role in the late phase of mitosis during which it is degraded by autophagy. Moreover, its dysregulation appears to be associated with the epithelial to mesen?chymal transition.
Publish Date	2015-11-23 10:19
Citation	Loukil A, Cheung CT, Bendris N, Lemmers B, Peter M, Blanchard JM. Cyclin A2: At the crossroads of cell cycle and cell invasion. World J Biol Chem 2015; 6(4): 346-350
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/346.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.346

Full Article (PDF)	WJBC-6-346.pdf
Full Article (Word)	WJBC-6-346.doc
Manuscript File	18283-Review.docx
Answering Reviewers	18283-Answering reviewers.pdf
Audio Core Tip	18283-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18283-Conflict-of-interest statement.pdf
Copyright License Agreement	18283-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20150414174454.pdf
Peer-review Report	18283-Peer-review(s).pdf
Scientific Misconduct Check	18283-Scientific misconduct check.pdf
Scientific Editor Work List	18283-Scientific editor work list.pdf