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11/9/2015 6:35:00 PM | Browse: 469 | Download: 801
Publication Name World Journal of Hepatology
Manuscript ID 18324
Country of Manuscript Source United States
2015-04-16 08:38
Peer-Review Started
2015-04-18 18:01
To Make the First Decision
2015-06-03 14:59
Return for Revision
2015-06-08 19:49
2015-09-23 08:33
Second Decision
2015-10-13 08:52
Accepted by Journal Editor-in-Chief
2015-10-16 20:24
Accepted by Company Editor-in-Chief
2015-10-27 17:48
Articles in Press
2015-10-27 17:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-30 17:22
Publish the Manuscript Online
2015-11-09 18:35
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic (type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Bharat K Puchakayala, Siddharth Verma, Pushpjeet Kanwar, John Hart, Raghavendra R Sanivarapu and Smruti R Mohanty
Funding Agency and Grant Number
Corresponding author Smruti R Mohanty, MD, MS, FACP, Center for Liver Diseases, Division of Gastroenterology and Hepatology, New York Methodist Hospital at Weill Cornell Medical College, 506 Sixth Street, 3rd Floor, Brooklyn, NY 11215, United States. srm9006@nyp.org
Keywords Non-alcoholic steatohepatitis; Non-alcoholic fatty liver disease; Advanced fibrosis; Non-alcoholic fatty liver disease activity score; Type 2 diabetes; Liver biopsy
Core Tip This retrospective cohort study shows that type 2 diabetes mellitus (T2DM) is a reliable predictor for both nonalcoholic steatohepatitis (NASH) and advanced fibrosis. Patients with nonalcoholic fatty liver disease (NAFLD) and uncontrolled T2DM tend to have advanced fibrosis and higher rate of ballooning histologically. It is important to recognize the differences between composite NAS and individual histological features while interpreting liver biopsies among NAFLD patients. Early diagnosis of NASH and advanced fibrosis in patients with NAFLD has important clinical significance espe-cially to prevent further progression of liver disease to cirrhosis, hepatocellular carcinoma and other related complications. Thus, optimization of risk factors for NAFLD such as metabolic syndrome, uncontrolled T2DM and dyslipidemia is of paramount importance.
Publish Date 2015-11-09 18:35
Citation Puchakayala BK, Verma S, Kanwar P, Hart J, Sanivarapu RR, Mohanty SR. Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic (type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease. World J Hepatol 2015; 7(25): 2610-2618
Url http://www.wjgnet.com/1948-5182/full/v7/i25/2610.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i25.2610
Full Article (PDF) WJH-7-2610.pdf
Full Article (Word) WJH-7-2610.doc
Manuscript File 18324-Review.doc
Answering Reviewers 18324-Answering reviewers.pdf
Audio Core Tip 18324-Audio core tip.wav
Biostatistics Review Certificate 18324-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 18324-Conflict-of-interest statement.pdf
Copyright License Agreement 18324-Copyright assignment.pdf
Data Sharing Statement 18324-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 18324-Institutional review board statement.pdf
Peer-review Report 18324-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 18324-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 18324-Scientific misconduct check.pdf
Scientific Editor Work List 18324-Scientific editor work list.pdf