Publication Name	World Journal of Hepatology
Manuscript ID	18324
Country	United States

Received	2015-04-16 08:38
Peer-Review Started	2015-04-18 18:01
To Make the First Decision	2015-06-03 14:59
Return for Revision	2015-06-08 19:49
Revised	2015-09-23 08:33
Second Decision	2015-10-13 08:52
Accepted by Journal Editor-in-Chief	2015-10-16 20:24
Accepted by Executive Editor-in-Chief	2015-10-27 17:48
Articles in Press	2015-10-27 17:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-30 17:22
Publish the Manuscript Online	2015-11-09 18:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic (type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Bharat K Puchakayala, Siddharth Verma, Pushpjeet Kanwar, John Hart, Raghavendra R Sanivarapu and Smruti R Mohanty
Funding Agency and Grant Number
Corresponding Author	Smruti R Mohanty, MD, MS, FACP, Center for Liver Diseases, Division of Gastroenterology and Hepatology, New York Methodist Hospital at Weill Cornell Medical College, 506 Sixth Street, 3rd Floor, Brooklyn, NY 11215, United States. srm9006@nyp.org
Key Words	Non-alcoholic steatohepatitis; Non-alcoholic fatty liver disease; Advanced fibrosis; Non-alcoholic fatty liver disease activity score; Type 2 diabetes; Liver biopsy
Core Tip	This retrospective cohort study shows that type 2 diabetes mellitus (T2DM) is a reliable predictor for both nonalcoholic steatohepatitis (NASH) and advanced fibrosis. Patients with nonalcoholic fatty liver disease (NAFLD) and uncontrolled T2DM tend to have advanced fibrosis and higher rate of ballooning histologically. It is important to recognize the differences between composite NAS and individual histological features while interpreting liver biopsies among NAFLD patients. Early diagnosis of NASH and advanced fibrosis in patients with NAFLD has important clinical significance espe-cially to prevent further progression of liver disease to cirrhosis, hepatocellular carcinoma and other related complications. Thus, optimization of risk factors for NAFLD such as metabolic syndrome, uncontrolled T2DM and dyslipidemia is of paramount importance.
Publish Date	2015-11-09 18:35
Citation	Puchakayala BK, Verma S, Kanwar P, Hart J, Sanivarapu RR, Mohanty SR. Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic (type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease. World J Hepatol 2015; 7(25): 2610-2618
URL	http://www.wjgnet.com/1948-5182/full/v7/i25/2610.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i25.2610

Full Article (PDF)	WJH-7-2610.pdf
Full Article (Word)	WJH-7-2610.doc
Manuscript File	18324-Review.doc
Answering Reviewers	18324-Answering reviewers.pdf
Audio Core Tip	18324-Audio core tip.wav
Biostatistics Review Certificate	18324-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	18324-Conflict-of-interest statement.pdf
Copyright License Agreement	18324-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	18324-Institutional review board statement.pdf
Peer-review Report	18324-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18324-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18324-Scientific misconduct check.pdf
Scientific Editor Work List	18324-Scientific editor work list.pdf