Publication Name	World Journal of Gastroenterology
Manuscript ID	18325
Country	Taiwan

Received	2015-04-16 16:41
Peer-Review Started	2015-04-18 15:57
To Make the First Decision	2015-05-18 13:03
Return for Revision	2015-05-20 11:07
Revised	2015-05-28 19:53
Second Decision	2015-07-27 19:57
Accepted by Journal Editor-in-Chief	2015-07-27 21:38
Accepted by Executive Editor-in-Chief	2015-08-31 16:20
Articles in Press	2015-08-31 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-09 23:48
Typeset the Manuscript	2015-09-21 14:51
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Zebrafish as a disease model for studying human hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Jeng-Wei Lu, Yi-Jung Ho, Yi-Ju Yang, Heng-An Liao, Shih-Ci Ciou, Liang-In Lin and Da-Liang Ou
Funding Agency and Grant Number	Funding Agency Grant Number National Science Council NSC 102-2314-B-002-142-MY3 National Science Council NSC-102-2628-B-002-029-MY3
Corresponding Author	Da-Liang Ou, PhD, Graduate Institute of Oncology, College of Medicine, National Taiwan University, 5F, No.2, Xuzhou Road, Taipei 100, Taiwan. dlou@ntu.edu.tw
Key Words	Cancer model; Hepatocellular carcinoma; Liver disease; Zebrafish; Drug screening
Core Tip	Hepatocellular carcinoma is one of the major cancers in the world and involves multiple mechanisms of tumor formation. Recently, the zebrafish has gained acceptance as a platform for developmental biology, drug toxicology, and translational medical research, offering innovative methods for studying disease and cancer formation. In this article, we summarize recent advances in the study of HCC based on the zebrafish as a model system through the use of transgenesis tools, genome editing technology, xenografts, drug hepatotoxicity, and novel drug discovery. Finally, we emphasize how each system works and how the technology was used in this cancer model.
Publish Date	2015-11-11 13:34
Citation	Lu JW, Ho YJ, Yang YJ, Liao HA, Ciou SC, Lin LI, Ou DL. Zebrafish as a disease model for studying human hepatocellular carcinoma. World J Gastroenterol 2015; 21(42): 12042-12058
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/12042.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.12042

Full Article (PDF)	WJG-21-12042.pdf
Full Article (Word)	WJG-21-12042.doc
Manuscript File	18325-Review.doc
Answering Reviewers	18325-Answering reviewers.pdf
Audio Core Tip	18325-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18325-Conflict-of-interest statement.pdf
Copyright License Agreement	18325-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18325-Language certificate.pdf
Peer-review Report	18325-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18325-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18325-Scientific misconduct check.pdf
Scientific Editor Work List	18325-Scientific editor work list.pdf