Publication Name	World Journal of Gastroenterology
Manuscript ID	18366
Country	Spain

Received	2015-04-18 11:13
Peer-Review Started	2015-04-19 18:02
To Make the First Decision	2015-06-23 14:51
Return for Revision	2015-06-26 13:42
Revised	2015-06-29 00:26
Second Decision	2015-09-12 21:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-14 11:12
Articles in Press	2015-09-14 11:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-23 11:19
Publish the Manuscript Online	2015-10-19 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Topic Highlights
Article Title	Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Antonio Cuadrado, David San Segundo, Marcos López-Hoyos, Javier Crespo and Emilio Fábrega
Funding Agency and Grant Number
Corresponding Author	Dr. Emilio Fábrega, MD, PhD, Gastro­enterology and Hepatology Unit, Marqués de Valdecilla University Hospital, Avenida Valdecilla s/n, 39008 Santander, Cantabria. Spain. digfge@humv.es
Key Words	Donor-specific anti-human leukocyte antigen antibodies; Liver transplantation; Rejection; Acute antibody-mediated rejection; C4d; Solid-phase immunoassays; Human leukocyte antigen single antigen bead
Core Tip	The role of donor-specific anti-human leukocyte antigen antibodies (DSA) in liver transplant (LT) remains unclear. Alloantibody-mediated adverse consequences are increasingly being recognized, and several cases of acute antibody-mediated rejection after ABO-compatible LT have been reported. There is a need to investigate and quantify the potential adverse impact of DSA on LT outcomes. The present review addresses the current knowledge on this issue.
Publish Date	2015-10-19 09:14
Citation	Cuadrado A, San Segundo D, López-Hoyos M, Crespo J, Fábrega E. Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation. World J Gastroenterol 2015; 21(39): 11016-11026
URL	http://www.wjgnet.com/1007-9327/full/v21/i39/11016.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i39.11016

Full Article (PDF)	WJG-21-11016.pdf
Full Article (Word)	WJG-21-11016.doc
Manuscript File	18366-Review.docx
Answering Reviewers	18366-Answering reviewers.pdf
Audio Core Tip	18366-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18366-Conflict-of-interest statement.pdf
Copyright License Agreement	18366-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18366-Language certificate.pdf
Peer-review Report	18366-Peer-review(s).pdf
Scientific Misconduct Check	18366-Scientific misconduct check.pdf
Scientific Editor Work List	18366-Scientific editor work list.pdf