Publication Name	World Journal of Hepatology
Manuscript ID	18413
Country	Egypt

Received	2015-04-20 11:37
Peer-Review Started	2015-04-21 16:36
To Make the First Decision	2015-07-17 16:31
Return for Revision	2015-07-21 09:51
Revised	2015-08-05 04:45
Second Decision	2015-09-02 10:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-08 15:47
Articles in Press	2015-09-08 15:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-15 11:18
Publish the Manuscript Online	2015-10-02 19:06

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biotechnology & Applied Microbiology
Manuscript Type	Review
Article Title	Monoclonal antibodies: Principles and applications of immmunodiagnosis and immunotherapy for hepatitis C virus
Manuscript Source	Invited Manuscript
All Author List	Ashraf Tabll, Aymn T Abbas, Sherif El-Kafrawy and Ahmed Wahid
Funding Agency and Grant Number
Corresponding Author	Ashraf Tabll, PhD, Head, Microbial Biotechnology Department (Biomedical Technology Group), Genetic Engineering and Biotechnology Division, National Research Centre, El Behoose Street, Dokki 12622, Egypt. ashraf.tabll@yale.edu
Key Words	Hepatitis C virus; Monoclonal antibodies; Immunodiagnosis; Immunotherapy
Core Tip	The monoclonal antibodies (mAb) of mice are predominantly used for the immunodiagnosis of several viral, bacterial, and parasitic antigens. Human mAb are used in the immunotherapy of several blood malignancies, such as lymphoma and leukemia, as well as for autoimmune diseases. In this review, we discuss methods of mouse and human monoclonal antibody production. We will demonstrate the role of mouse mAb in the detection of hepatitis C virus (HCV) antigens as rapid and sensitive immunodiagnostic assays. We will also discuss the role of HCV-neutralizing antibodies in the immunotherapy of HCV infections and in HCV vaccine development.
Publish Date	2015-10-02 19:06
Citation	Tabll A, Abbas AT, El-Kafrawy S, Wahid A. Monoclonal antibodies: Principles and applications of immmunodiagnosis and immunotherapy for hepatitis C virus. World J Hepatol 2015; 7(22): 2369-2383
URL	http://www.wjgnet.com/1948-5182/full/v7/i22/2369.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i22.2369

Full Article (PDF)	WJH-7-2369.pdf
Full Article (Word)	WJH-7-2369.doc
Manuscript File	18413-Review.doc
Answering Reviewers	18413-Answering reviewers.pdf
Audio Core Tip	18413-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	18413-Conflict-of-interest statement.pdf
Copyright License Agreement	18413-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18413-Language certificate.pdf
Peer-review Report	18413-Peer-review(s).pdf
Scientific Misconduct Check	18413-Scientific misconduct check.pdf
Scientific Editor Work List	18413-Scientific editor work list.pdf