Publication Name	World Journal of Gastroenterology
Manuscript ID	18469
Country	Japan

Received	2015-04-21 16:07
Peer-Review Started	2015-04-22 16:18
To Make the First Decision	2015-06-02 16:10
Return for Revision	2015-06-08 10:20
Revised	2015-06-11 08:39
Second Decision	2015-07-27 20:20
Accepted by Journal Editor-in-Chief	2015-07-29 11:54
Accepted by Executive Editor-in-Chief	2015-08-25 18:48
Articles in Press	2015-08-25 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-21 15:48
Typeset the Manuscript	2015-09-23 12:13
Publish the Manuscript Online	2015-10-19 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Topic Highlights
Article Title	Anticancer effect of adenosine on gastric cancer via diverse signaling pathways
Manuscript Source	Invited Manuscript
All Author List	Ayako Tsuchiya and Tomoyuki Nishizaki
Funding Agency and Grant Number
Corresponding Author	Tomoyuki Nishizaki, MD, PhD, Professor, Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan. tomoyuki@hyo-med.ac.jp
Key Words	Adenosine; Apoptosis; Intrinsic pathway; Extrinsic pathway; Gastric cancer
Core Tip	Emerging evidence has pointed to adenosine as a tumor suppressor. The most crucial problem for chemotherapy is side effects. Adenosine is an endogenous substance, and therefore, no or fewer side effects are expected for chemotherapy using adenosine. Extracellular adenosine induces apoptosis of gastric cancer cells through intrinsic and extrinsic signaling pathways. Adenosine and its signaling cascades, therefore, could represent a promising drug for gastric cancer chemotherapy. Moreover, the contribution of each downstream target molecule of adenosine to apoptosis induction may aid the establishment of tailor-made chemotherapy for gastric cancer.
Publish Date	2015-10-19 09:14
Citation	Tsuchiya A, Nishizaki T. Anticancer effect of adenosine on gastric cancer via diverse signaling pathways. World J Gastroenterol 2015; 21(39): 10931-10935
URL	http://www.wjgnet.com/1007-9327/full/v21/i39/10931.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i39.10931

Full Article (PDF)	WJG-21-10931.pdf
Full Article (Word)	WJG-21-10931.doc
Manuscript File	18469-Review.doc
Answering Reviewers	18469-Answering reviewers.pdf
Audio Core Tip	18469-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18469-Conflict-of-interest statement.psd
Copyright License Agreement	18469-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18469-edited.doc
Peer-review Report	18469-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18469-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18469-Scientific misconduct check.pdf
Scientific Editor Work List	18469-Scientific editor work list.pdf