Publication Name	World Journal of Gastroenterology
Manuscript ID	18470
Country	South Korea

Received	2015-04-21 16:19
Peer-Review Started	2015-04-22 16:33
First Decision by Editorial Office Director
Return for Revision	2015-08-28 16:56
Revised	2015-09-08 08:45
Publication Fee Transferred
Second Decision by Editor	2015-10-10 18:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-10-13 17:47
Articles in Press	2015-10-13 17:47
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-06 14:27
Publish the Manuscript Online	2016-01-15 14:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Byungho Lim, Jong-Hwan Kim, Mirang Kim and Seon-Young Kim
Funding Agency and Grant Number	Funding Agency Grant Number the genomics program of the National Research Foundation of Korea funded by the Ministry of Science, ICT, and Future Planning NRF-2012M3A9D1054670 the genomics program of the National Research Foundation of Korea funded by the Ministry of Science, ICT, and Future Planning NRF-2014M3C9A3068554 (to Kim SY) Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education NRF-2013R1A1A2006621 (to Kim M) Korea Research Institute of Bioscience and Biotechnology research initiative grant
Corresponding Author	Seon-Young Kim, PhD, Genome Structure Research Center, Korea Research Institute of Bio­science and Biotechnology, Daejeon 305-806, South Korea. kimsy@kribb.re.kr
Key Words	DNA methylation; Gastric cancer; Molecular subtype; Mutation; Next-generation sequencing
Core Tip	For the effective diagnosis and treatment of gastric cancer, a recent sequencing study classified gastric cancer into four molecular subtypes, which include Epstein-Barr virus-positive, microsatellite instability, genomically stable, and chromosomal instability subtypes. This molecular subtyping will extend our knowledge for basic research and will be valuable for clinical uses. We herein discuss the genomic and epigenomic heterogeneity of the four molecular subtypes of gastric cancer. We also describe a meta-analysis result that was performed using previously reported sequencing datasets.
Publish Date	2016-01-15 14:54
Citation	Lim B, Kim JH, Kim M, Kim SY. Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer. World J Gastroenterol 2016; 22(3): 1190-1201
URL	http://www.wjgnet.com/1007-9327/full/v22/i3/1190.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i3.1190

Full Article (PDF)	WJG-22-1190.pdf
Full Article (Word)	WJG-22-1190.doc