Publication Name	World Journal of Gastroenterology
Manuscript ID	18480
Country	China

Received	2015-04-22 09:23
Peer-Review Started	2015-04-22 19:35
To Make the First Decision	2015-06-19 17:37
Return for Revision	2015-06-24 16:31
Revised	2015-07-02 18:27
Second Decision	2015-08-10 08:19
Accepted by Journal Editor-in-Chief	2015-08-11 15:45
Accepted by Executive Editor-in-Chief	2015-08-31 17:26
Articles in Press	2015-08-31 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-19 00:39
Typeset the Manuscript	2015-09-24 10:11
Publish the Manuscript Online	2015-10-14 12:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Lin Sun, Jian-Qiang Cai, Fang Liu, Xin-Yu Bi, Lan-Ping Zhou and Xiao-Hang Zhao
Funding Agency and Grant Number	Funding Agency Grant Number State Key Project for Infectious Diseases 2013ZX10002009 State Key Project for Infectious Diseases 2012ZX10002-017 National Basic Research Program of China 2014CBA02001 National Basic Research Program of China 2014CBA02002 National High-tech R&D Program of China 2012AA020206 National Natural Science Foundation of China 81071789 National Natural Science Foundation of China 81321091
Corresponding Author	Xiao-Hang Zhao, MD, PhD, Professor, State Key Laboratory of Molecular Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuan Nanli 17, Chaoyang District, Beijing 100021, China. zhaoxh@cicams.ac.cn
Key Words	Peroxiredoxin 1; Liver cancer; Prognostic factor; Post-translational modification; SUMOylation
Core Tip	Peroxiredoxin 1 (PRDX1) is an antioxidant enzyme, and, therefore, it is considered a tumor suppressor gene. However, only recently has various data revealed that PRDX1 not only functions in peroxide detoxification but also in tumorigenesis. Here, we found that PRDX1 was overexpressed in liver cancer at the transcriptional level, and it was an independent unfavorable prognostic factor for overall survival. In liver cancer cells, PRDX1 is post-translationally modified by small ubiquitin-like modifier. The downregulation of sumoylated PRDX1 in tumors might participate in hepatocarcinogenesis. PRDX1 represents both a prognostic biomarker and therapeutic target for liver cancer.
Publish Date	2015-10-14 12:06
Citation	Sun YL, Cai JQ, Liu F, Bi XY, Zhou LP, Zhao XH. Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer. World J Gastroenterol 2015; 21(38): 10840-10852
URL	http://www.wjgnet.com/1007-9327/full/v21/i38/10840.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i38.10840

Full Article (PDF)	WJG-21-10840.pdf
Full Article (Word)	WJG-21-10840.doc
Manuscript File	18480-Review.doc
Answering Reviewers	18480-Answering reviewers.pdf
Audio Core Tip	18480-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18480-Conflict-of-interest statement.pdf
Copyright License Agreement	18480-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	18480-Institutional review board statement.pdf
Peer-review Report	18480-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18480-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18480-Scientific misconduct check.pdf
Scientific Editor Work List	18480-Scientific editor work list.pdf