Publication Name	World Journal of Hepatology
Manuscript ID	1849
Country	Germany

Received	2013-01-10 08:39
Peer-Review Started	2013-01-10 17:23
To Make the First Decision	2013-03-04 11:51
Return for Revision	2013-03-08 11:40
Revised	2013-03-11 21:46
Second Decision	2013-06-19 12:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-20 00:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-15 10:09
Publish the Manuscript Online	2013-07-25 09:10

ISSN	1948-5182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests
Manuscript Source	Invited Manuscript
All Author List	Rolf Teschke, Christian Frenzel, Johannes Schulze, Alexander Schwarzenboeck and Axel Eickhoff
Funding Agency and Grant Number
Corresponding Author	Rolf Teschke, Professor, Department of Internal Medicine Ⅱ, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University of Frankfurt/Main, Leimenstrasse 20, D-63450 Hanau, Germany. rolf.teschke@gmx.de
Key Words	Herbalife hepatotoxicity; Herbalife induced liver injury; Herbal hepatotoxicity; Herb induced liver injury; Herbs
Core Tip	Our analysis focuses on published cases of suspected Herbalife hepatotoxicity with positive reexposure tests and high causality gradings. Problems included poorly fulfilled test criteria, numerous confounding variables, and the use of liver unspecific, obsolete causality assessment methods. Submitting the case data to well established criteria for positive reexposure tests, the test was positive in 1/8 cases and negative or uninterpretable in the other cases. Using the liver specific Council for International Organizations of Medical Sciences scale, causality was probable in 1 case, unlikely and excluded in the other cases. Thus, causality levels were much lower than hitherto proposed.
Publish Date	2013-07-25 09:10
Citation	Teschke R, Frenzel C, Schulze J, Schwarzenboeck A, Eickhoff A. Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests. World J Hepatol 2013; 5(7): 353-363
URL	http://www.wjgnet.com/1948-5182/full/v5/i7/353.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i7.353

Full Article (PDF)	WJH-5-353.pdf
Manuscript File	1849-Review.doc
Answering Reviewers	1849-Answering reviewers.pdf
Copyright License Agreement	1849-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1849-Language certificate.pdf
Peer-review Report	1849-Peer review(s).pdf
Scientific Editor Work List	1849-Scientific editor work list.doc