Publication Name	World Journal of Gastroenterology
Manuscript ID	18491
Country	Switzerland

Received	2015-04-22 08:50
Peer-Review Started	2015-04-23 10:01
To Make the First Decision	2015-07-20 14:38
Return for Revision	2015-08-02 00:42
Revised	2015-08-31 15:17
Second Decision	2015-11-03 08:55
Accepted by Journal Editor-in-Chief	2015-11-03 14:20
Accepted by Company Editor-in-Chief	2015-11-19 16:26
Articles in Press	2015-11-19 16:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-17 21:25
Publish the Manuscript Online	2016-01-15 14:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Marianne R Spalinger, Declan F McCole, Gerhard Rogler and Michael Scharl
Funding Agency and Grant Number	Funding Agency Grant Number Swiss National Science Foundation (SNF) to MS 314730-146204 (to Rogler G) Swiss National Science Foundation (SNF) to MS CRSII3_154488/1 (to Rogler G) Swiss National Science Foundation (SNF) to MS 310030-120312 Swiss IBD Cohort 3347CO-108792
Corresponding Author	Michael Scharl, MD, Division of Gastroenterology and Hepatology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland. michael.scharl@usz.ch
Key Words	Protein tyrosine phosphatase non-receptor type 2; Inflammatory bowel disease; Chronic intestinal inflammation; Barrier function; Phosphorylation
Core Tip	Genetic variants and subsequently aberrant function of protein tyrosine phosphatase non-receptor type 2 (PTPN2) have been associated with inflammatory bowel disease (IBD). Protein levels of PTPN2 are increased in the mucosa of IBD patients and PTPN2-deficient mice suffer from severe intestinal as well as systemic inflammation and feature alterations in innate and adaptive immune responses. In the innate immune system, dysfunction of PTPN2 results in increased secretion of pro-inflammatory cytokines, impairs autophagosome formation, and mediates disruption of epithelial barrier function. In the adaptive immune system, PTPN2 is involved in controlling T-cell proliferation, differentiation and promoting T-cell tolerance. Consequently, variants in PTPN2 importantly affect intestinal homeostasis and contribute to IBD pathogenesis.
Publish Date	2016-01-15 14:54
Citation	Spalinger MR, McCole DF, Rogler G, Scharl M. Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease. World J Gastroenterol 2016; 22(3): 1034-1044
URL	http://www.wjgnet.com/1007-9327/full/v22/i3/1034.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i3.1034

Full Article (PDF)	WJG-22-1034.pdf
Full Article (Word)	WJG-22-1034.doc
Manuscript File	18491-Review.docx
Answering Reviewers	18491-Answering reviewers.pdf
Audio Core Tip	18491-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18491-Conflict-of-interest statement.pdf
Copyright License Agreement	18491-Copyright assignment.pdf
Peer-review Report	18491-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18491-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18491-Scientific misconduct check.pdf
Scientific Editor Work List	18491-Scientific editor work list.pdf