Publication Name	World Journal of Gastroenterology
Manuscript ID	18521
Country	Spain

Received	2015-04-23 09:08
Peer-Review Started	2015-04-24 09:39
To Make the First Decision	2015-05-18 12:22
Return for Revision	2015-05-22 11:13
Revised	2015-06-05 00:40
Second Decision	2015-07-17 17:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-18 11:20
Articles in Press	2015-07-18 11:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-11 15:27
Publish the Manuscript Online	2015-08-28 17:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Paloma Lluch, Gloria Segarra and Pascual Medina
Funding Agency and Grant Number	Funding Agency Grant Number University of Valencia, Instituto de Salud Carlos III Consellería de Sanidad, Generalitat Valenciana
Corresponding Author	Pascual Medina, PhD, Department of Physiology, University of Valencia and Institute of Health Research INCLIVA, Hospital Clínico Universitario Valencia, Avenida Blasco Ibáñez 15, 46010 Valencia, Spain. pascual.medina@uv.es
Key Words	Dimethylarginine dimethylaminohydrolase; Nitric oxide; Liver diseases; Dimethylarginines; Endothelial function
Core Tip	Several lines of evidence point out that the liver is an important organ clearing asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase and a mediator of elevated intrahepatic vascular tone in cirrhosis. ADMA is degraded by dimethylarginine dimethylaminohydrolases that are expressed widely in the liver. Therefore, liver dysfunction could lead to alterations in the levels of ADMA and modifies nitric oxide bioavailability. Our increasing understanding of the routes of synthesis and metabolism of methylarginines is beginning to provide insights into novel mechanisms of liver disease and allowing us to identify potential therapeutic opportunities.
Publish Date	2015-08-28 17:04
Citation	Lluch P, Segarra G, Medina P. Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis. World J Gastroenterol 2015; 21(32): 9466-9475
URL	http://www.wjgnet.com/1007-9327/full/v21/i32/9466.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i32.9466

Full Article (PDF)	WJG-21-9466.pdf
Full Article (Word)	WJG-21-9466.doc
Manuscript File	18521-Review.doc
Answering Reviewers	18521-Answering reviewers.pdf
Audio Core Tip	18521-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18521-Conflict-of-interest statement.pdf
Copyright License Agreement	18521-Copyright assignment.pdf
Peer-review Report	18521-Peer-review(s).pdf
Scientific Misconduct Check	18521-Scientific misconduct check.pdf
Scientific Editor Work List	18521-Scientific editor work list.pdf