BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/3/2015 8:26:00 AM | Browse: 1206 | Download: 2841
 |
Received |
|
2015-04-23 08:37 |
|
Peer-Review Started |
|
2015-05-03 08:54 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2015-06-09 10:59 |
|
Revised |
|
2015-06-24 02:15 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2015-08-27 11:38 |
|
Second Decision by Editor-in-Chief |
|
2015-08-27 15:37 |
|
Final Decision by Editorial Office Director |
|
2015-09-08 15:13 |
|
Articles in Press |
|
2015-09-08 15:13 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2015-10-12 16:31 |
|
Publish the Manuscript Online |
|
2015-11-03 08:25 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jing Huang, John H Wolk, Michael H Gewitz, James E Loyd, James West, Eric D Austin and Rajamma Mathew |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NYMC Research Endowment Fund under the College’s intramural support program (RM) |
|
| National Institutes of Health (JEL) |
R01 HL111259 |
| National Institutes of Health (EDA) |
K23 HL098743 |
|
| Corresponding Author |
Rajamma Mathew, MD, Department of Physiology, New York Medical College, Rm # A11, Basic Science Building, Valhalla, NY 10595,
United States. rajamma_mathew@nymc.edu
|
| Key Words |
Endothelial cells; Neointima; Pulmonary hypertension; Smooth muscle cells |
| Core Tip |
Neointima in pulmonary hypertension (PH) is associated with poor prognosis. Caveolin-1, a cell membrane protein has a critical role in PH. We investigated the association of caveolin-1 and neointima formation in monocrotaline (MCT) + hypoxia-treated rats, and in human PH lung sections. The progressive caveolin-1 reduction in endothelial cells is followed by an increased caveolin-1 expression in smooth muscle cells (SMC). In human PH as well as in the MCT + hypoxia model, neointima was observed only in the arteries exhibiting an increased caveolin-1 expression in SMC. Thus, the increased caveolin-1 expression in SMC may in part, facilitate neointima formation. |
| Publish Date |
2015-11-03 08:25 |
| Citation |
Huang J, Wolk JH, Gewitz MH, Loyd JE, West J, Austin ED, Mathew R. Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation. World J Cardiol 2015; 7(10): 671-684 |
| URL |
http://www.wjgnet.com/1949-8462/full/v7/i10/671.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v7.i10.671 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
