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Articles Published Processes
11/3/2015 8:26:00 AM | Browse: 1001 | Download: 2103
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Received |
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2015-04-23 08:37 |
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Peer-Review Started |
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2015-05-03 08:54 |
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To Make the First Decision |
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2015-06-03 14:20 |
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Return for Revision |
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2015-06-09 10:59 |
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Revised |
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2015-06-24 02:15 |
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Second Decision |
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2015-08-27 11:38 |
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Accepted by Journal Editor-in-Chief |
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2015-08-27 15:37 |
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Accepted by Executive Editor-in-Chief |
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2015-09-08 15:13 |
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Articles in Press |
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2015-09-08 15:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-12 16:31 |
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Publish the Manuscript Online |
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2015-11-03 08:25 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jing Huang, John H Wolk, Michael H Gewitz, James E Loyd, James West, Eric D Austin and Rajamma Mathew |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NYMC Research Endowment Fund under the College’s intramural support program (RM) |
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| National Institutes of Health (JEL) |
R01 HL111259 |
| National Institutes of Health (EDA) |
K23 HL098743 |
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| Corresponding Author |
Rajamma Mathew, MD, Department of Physiology, New York Medical College, Rm # A11, Basic Science Building, Valhalla, NY 10595,
United States. rajamma_mathew@nymc.edu
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| Key Words |
Endothelial cells; Neointima; Pulmonary hypertension; Smooth muscle cells |
| Core Tip |
Neointima in pulmonary hypertension (PH) is associated with poor prognosis. Caveolin-1, a cell membrane protein has a critical role in PH. We investigated the association of caveolin-1 and neointima formation in monocrotaline (MCT) + hypoxia-treated rats, and in human PH lung sections. The progressive caveolin-1 reduction in endothelial cells is followed by an increased caveolin-1 expression in smooth muscle cells (SMC). In human PH as well as in the MCT + hypoxia model, neointima was observed only in the arteries exhibiting an increased caveolin-1 expression in SMC. Thus, the increased caveolin-1 expression in SMC may in part, facilitate neointima formation. |
| Publish Date |
2015-11-03 08:25 |
| Citation |
Huang J, Wolk JH, Gewitz MH, Loyd JE, West J, Austin ED, Mathew R. Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation. World J Cardiol 2015; 7(10): 671-684 |
| URL |
http://www.wjgnet.com/1949-8462/full/v7/i10/671.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v7.i10.671 |
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