Publication Name	World Journal of Gastroenterology
Manuscript ID	18558
Country	Italy

Received	2015-04-23 17:24
Peer-Review Started	2015-04-24 17:26
To Make the First Decision	2015-06-02 15:18
Return for Revision	2015-06-08 13:11
Revised	2015-06-11 19:32
Second Decision	2015-08-21 13:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-02 15:11
Articles in Press	2015-09-02 15:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-15 00:08
Typeset the Manuscript	2015-09-25 14:14
Publish the Manuscript Online	2015-10-19 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Genetic background in nonalcoholic fatty liver disease: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Fabio Salvatore Macaluso, Marcello Maida and Salvatore Petta
Funding Agency and Grant Number
Corresponding Author	Fabio Salvatore Macaluso, MD, Section of Gastroenterology, DIBIMIS, University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy. fsmacaluso@gmail.com
Key Words	Nonalcoholic fatty liver disease; Nonal­coholic steatohepatitis; Genetics; Genome-wide asso­ciation studies; Patatin-like phospholipase domain-containing 3; Transmembrane 6 superfamily member 2; Candidate gene studies
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is regarded as the most significant liver disease from the twenty-first century in the Western world. Although its development is surely driven by environmental factors, it is also regulated by genetic background. The role of heritability has been widely demonstrated by several studies, likely reflecting the diverse genetic variability in systemic metabolism and wound healing response processes. Accordingly, we performed a review of the literature on the role of genetics in NAFLD and outlined here the putative role of each genetic variant in influencing susceptibility and/or progression of the disease.
Publish Date	2015-10-19 09:14
Citation	Macaluso FS, Maida M, Petta S. Genetic background in nonalcoholic fatty liver disease: a comprehensive review. World J Gastroenterol 2015; 21(39): 11088-11111
URL	http://www.wjgnet.com/1007-9327/full/v21/i39/11088.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i39.11088

Full Article (PDF)	WJG-21-11088.pdf
Full Article (Word)	WJG-21-11088.doc
Manuscript File	18558-Review.doc
Answering Reviewers	18558-Answering reviewers.pdf
Audio Core Tip	18558-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18558-Conflict-of-interest statement.pdf
Copyright License Agreement	18558-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18558-Language certificate.pdf
Peer-review Report	18558-Peer-review(s).pdf
Scientific Misconduct Check	18558-Scientific misconduct check.pdf
Scientific Editor Work List	18558-Scientific editor work list.pdf