Publication Name	World Journal of Hepatology
Manuscript ID	18563
Country	Italy

Received	2015-04-24 09:23
Peer-Review Started	2015-04-24 17:35
First Decision by Editorial Office Director
Return for Revision	2015-08-10 17:23
Revised	2015-09-29 15:39
Publication Fee Transferred
Second Decision by Editor	2015-12-07 09:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-12-18 16:45
Articles in Press	2015-12-18 16:46
Edit the Manuscript by Language Editor	2015-12-31 09:41
Typeset the Manuscript	2016-01-11 19:02
Publish the Manuscript Online	2016-01-15 09:49

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Chronic hepatitis C: This and the new era of treatment
Manuscript Source	Invited Manuscript
All Author List	Gaetano Bertino, Annalisa Ardiri, Maria Proiti, Giuseppe Rigano, Evelise Frazzetto, Shirin Demma, Maria Irene Ruggeri, Laura Scuderi, Giulia Malaguarnera, Nicoletta Bertino, Venerando Rapisarda, Isidoro Di Carlo, Adriana Toro, Federico Salomone, Mariano Malaguarnera, Emanuele Bertino and Michele Malaguarnera
Funding Agency and Grant Number
Corresponding Author	Gaetano Bertino, Professor, Hepatology Unit - Department of Clinical and Experimental Medicine, University of Catania, Policlinic - Via S. Sofia n. 78, 95123 Catania, Italy. gaetanobertinounict@libero.it
Key Words	Direct-acting antiviral agents; Nucleoside inhibitors; Boceprevir; Sofosbuvir; Telaprevir; Hepatitis C; Simeprevir; Daclatasvir; Ledipasvir; Faldaprevir; Ritonavir; Ombitasvir; Dasabuvir
Core Tip	This review analyzes the current therapies for chronic hepatitis C and the future challenges of the research. So it tries to give an update on the research of hepatitis C virus (HCV) infection, providing a critical view of the emerging therapies and their impact on the future management of HCV infection. Since novel treatments for HCV infection are highly efficacious but costly, priority should be given to patients with advanced hepatic fibrosis, which is a disease that cannot be deferred.
Publish Date	2016-01-15 09:49
Citation	Bertino G, Ardiri A, Proiti M, Rigano G, Frazzetto E, Demma S, Ruggeri MI, Scuderi L, Malaguarnera G, Bertino N, Rapisarda V, Di Carlo I, Toro A, Salomone F, Malaguarnera M, Bertino E, Malaguarnera M. Chronic hepatitis C: This and the new era of treatment. World J Hepatol 2016; 8(2): 92-106
URL	http://www.wjgnet.com/1948-5182/full/v8/i2/92.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i2.92

Full Article (PDF)	WJH-8-92.pdf
Full Article (Word)	WJH-8-92.doc