Publication Name	World Journal of Gastroenterology
Manuscript ID	18591
Country	Japan

Received	2015-04-24 17:35
Peer-Review Started	2015-04-24 20:26
To Make the First Decision	2015-06-02 16:09
Return for Revision	2015-06-08 11:36
Revised	2015-06-25 15:06
Second Decision	2015-08-19 14:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-02 15:12
Articles in Press	2015-09-02 15:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-10-30 00:08
Typeset the Manuscript	2015-11-29 18:43
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Nutrition & Dietetics
Manuscript Type	Topic Highlights
Article Title	Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes
Manuscript Source	Invited Manuscript
All Author List	Kyu-Ho Han, Naoto Hashimoto and Michihiro Fukushima
Funding Agency and Grant Number	Funding Agency Grant Number JSPS KAKENHI Grant 25450196 grants-in-aid from The Ministry of Agriculture, Forestry and Fisheries of Japan
Corresponding Author	Naoto Hashimoto, PhD, Upland Farming Resource Research Division, NARO Hokkaido Agricultural Research Center, Minami 9-4, Shinsei, Memuro, Kasai, Hokkaido 082-0071, Japan. hasshy@affrc.go.jp
Key Words	Electrophile; Mitogen-activating protein kinase; Plant antioxidants; reactive oxygen species; Preconditioning
Core Tip	The metabolic process of ethanol generates reactive oxygen species, which play a significant role in the deterioration of alcoholic liver disease (ALD). Antioxidant phytochemicals, such as polyphenols, upregulate the expression of antioxidant enzymes and peptides via the Kelch-like ECH-associated protein 1-NF-E2-related factor-2 pathway, which leads to antioxidant responsive elements in animal models. Furthermore, these antioxidants alleviate cell injury caused by oxidants or inflammatory cytokines via impairment of hyperactivation of mitogen-activating protein kinase pathways, similar to preconditioning in ischemia-reperfusion models. Although the relationship between plant antioxidants and ALD has not been adequately investigated, plant antioxidants may be preventive for ALD.
Publish Date	2015-12-31 13:27
Citation	Han KH, Hashimoto N, Fukushima M. Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes. World J Gastroenterol 2016; 22(1): 37-49
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/37.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.37

Full Article (PDF)	WJG-22-37.pdf
Full Article (Word)	WJG-22-37.doc
Manuscript File	18591-Review.docx
Answering Reviewers	18591-Answering reviewers.pdf
Audio Core Tip	18591-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18591-Conflict-of-interest statement.pdf
Copyright License Agreement	18591-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18591-Language certificate.pdf
Peer-review Report	18591-Peer-review(s).pdf
Scientific Misconduct Check	18591-Scientific misconduct check.pdf
Scientific Editor Work List	18591-Scientific editor work list.pdf