Publication Name	World Journal of Cardiology
Manuscript ID	18612
Country	Germany

Received	2015-04-25 11:12
Peer-Review Started	2015-04-26 12:46
To Make the First Decision	2015-05-13 19:32
Return for Revision	2015-05-19 12:17
Revised	2015-05-28 00:11
Second Decision	2015-06-08 11:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-06-16 16:44
Articles in Press	2015-06-16 16:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-07 15:35
Publish the Manuscript Online	2015-08-04 13:14

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	Impairment of aspirin antiplatelet effects by non-opioid analgesic medication
Manuscript Source	Invited Manuscript
All Author List	Amin Polzin, Thomas Hohlfeld, Malte Kelm and Tobias Zeus
Funding Agency and Grant Number	Funding Agency Grant Number Forschungskommission of the Medical Faculty of the Heinrich Heine University 16-2014(to AP)
Corresponding Author	Dr. Med. Amin Polzin, MD, Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany. amin.polzin@med.uni-duesseldorf.de
Key Words	Non-steroidal anti-inflammatory drug; Drug-drug interaction; Pharmacodynamic; Dipyrone; Aspirin; Paracetamol; Metamizole
Core Tip	Aspirin is the mainstay in prophylaxis of cardiovascular diseases. Impaired aspirin antiplatelet effects are associated with enhanced incidence of cardiovascular events. Comedication with non-opioid analgesic drugs has been described to interfere with aspirin, resulting in impaired aspirin antiplatelet effects. Additionally, non-opioid analgesic medication has been shown to enhance the risk of cardiovascular events and death. Pain is very frequent and many patients rely on analgesic drugs to control pain. Therefore effective analgesic options without increased risk of cardiovascular events are desirable. This review focuses on commonly used non-opioid analgesics, interactions with aspirin medication and impact on cardiovascular risk.
Publish Date	2015-08-04 13:14
Citation	Polzin A, Hohlfeld T, Kelm M, Zeus T. Impairment of aspirin antiplatelet effects by non-opioid analgesic medication. World J Cardiol 2015; 7(7): 383-391
URL	http://www.wjgnet.com/1949-8462/full/v7/i7/383.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i7.383

Full Article (PDF)	WJC-7-383.pdf
Full Article (Word)	WJC-7-383.doc
Manuscript File	18612-Review.docx
Answering Reviewers	18612-Answering reviewers.pdf
Audio Core Tip	18612-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18612-Conflict-of-interest statement.pdf
Copyright License Agreement	18612-Copyright assignment.pdf
Peer-review Report	18612-Peer-review(s).pdf
Scientific Misconduct Check	18612-Scientific misconduct check.pdf
Scientific Editor Work List	18612-Scientific editor work list.pdf