Publication Name	World Journal of Gastroenterology
Manuscript ID	18632
Country	France

Received	2015-04-26 13:02
Peer-Review Started	2015-04-27 08:37
To Make the First Decision	2015-09-11 09:21
Return for Revision	2015-09-14 20:24
Revised	2015-09-25 18:30
Second Decision	2015-10-10 18:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-13 18:21
Articles in Press	2015-10-13 18:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-13 09:33
Publish the Manuscript Online	2016-01-06 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Hussein Akil, Aurélie Perraud, Marie-Odile Jauberteau and Muriel Mathonnet
Funding Agency and Grant Number	Funding Agency Grant Number Conseil Régional du Limousin CORC Comité Orientation Recherche Cancer
Corresponding Author	Hussein Akil, PhD, Laboratoire Homéostasie Cellulaire et Pathologies (LHCP-EA3842), Faculté de Médecine et de Pharmacie, Fédération de Recherche GEIST, Université de Limoges, 2 rue du Dr Marcland, 87025 Limoges, France. hussein.akil@outlook.fr
Key Words	Colorectal cancer; Tyrosine kinase receptor B; Brain-derived neurotrophic factor; Therapeutic targets; Cell survival
Core Tip	Recently, the tropomyosin-related kinase B (TrkB)/brain derived-neurotrophic factor (BDNF) signaling pathway has emerged as a key player in the pathogenesis and prognosis of several non-neural cancers. Indeed, the TrkB tyrosine kinase receptor has been recently found to play an important role in the biological and clinical behavior of colorectal cancer (CRC). Here, we review the implications of TrkB and its ligand BDNF in CRC. Additionally, we discuss possible therapeutic strategies targeting this pathway.
Publish Date	2016-01-06 16:13
Citation	Akil H, Perraud A, Jauberteau MO, Mathonnet M. Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer. World J Gastroenterol 2016; 22(2): 490-500
URL	http://www.wjgnet.com/1007-9327/full/v22/i2/490.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i2.490

Full Article (PDF)	WJG-22-490.pdf
Full Article (Word)	WJG-22-490.doc
Manuscript File	18632-Review.doc
Answering Reviewers	18632-Answering reviewers.pdf
Audio Core Tip	18632-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18632-Conflict-of-interest statement.pdf
Copyright License Agreement	18632-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	18632-Language certificate.pdf
Peer-review Report	18632-Peer-review(s).pdf
Scientific Misconduct Check	18632-Scientific misconduct check.pdf
Scientific Editor Work List	18632-Scientific editor work list.pdf