Publication Name	World Journal of Gastroenterology
Manuscript ID	18654
Country	China

Received	2015-04-26 14:19
Peer-Review Started	2015-04-28 09:25
First Decision by Editorial Office Director
Return for Revision	2015-06-08 17:02
Revised	2015-06-19 09:57
Publication Fee Transferred
Second Decision by Editor	2015-08-21 13:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-09-02 15:13
Articles in Press	2015-09-02 15:14
Edit the Manuscript by Language Editor	2015-09-15 10:06
Typeset the Manuscript	2015-09-22 17:33
Publish the Manuscript Online	2015-10-14 12:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Restoring homeostasis of CD4+ T cells in hepatitis-B-virus-related liver fibrosis
Manuscript Source	Invited Manuscript
All Author List	Li-Sha Cheng, Yun Liu and Wei Jiang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81070341 National Natural Science Foundation of China 81270517
Corresponding Author	Wei Jiang, Professor, Department of Gastroenterology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China. jiang.wei@zs-hospital.sh.cn
Key Words	Homeostasis; Regulatory T cells; T helper 17 cells; CD4+ T cells; Liver fibrosis; Chronic hepatitis B; Pathogenesis; Therapy
Core Tip	Hepatitis B virus (HBV)-related liver fibrosis (HBVLF) is a reversible, intermediate stage of chronic hepatitis B and liver cirrhosis. The homeostasis of CD4+ T cells, especially the balance between regulatory T (Treg) cells and T helper 17 (Th17) cells is pivotal in HBVLF. Therefore, uncovering the underlying mechanisms of CD4+ T cell homeostasis regulating HBVLF may help achieve better clinical outcomes. We discuss Treg and Th17 cell-related cytokines and surface molecules that may be targeted therapeutically to alter CD4+ T-cell homeostasis in chronic HBV infection.
Publish Date	2015-10-14 12:06
Citation	Cheng LS, Liu Y, Jiang W. Restoring homeostasis of CD4+ T cells in hepatitis-B-virus-related liver fibrosis. World J Gastroenterol 2015; 21(38): 10721-10731
URL	http://www.wjgnet.com/1007-9327/full/v21/i38/10721.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i38.10721

Full Article (PDF)	WJG-21-10721.pdf
Full Article (Word)	WJG-21-10721.doc
Manuscript File	18654-Review.docx
Answering Reviewers	18654-Answering reviewers.pdf
Audio Core Tip	18654-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18654-Conflict-of-interest statement.pdf
Copyright License Agreement	18654-Copyright assignment.pdf
Peer-review Report	18654-Peer-review(s).pdf
Scientific Misconduct Check	18654-Scientific misconduct check.pdf
Scientific Editor Work List	18654-Scientific editor work list.pdf