Publication Name	World Journal of Gastroenterology
Manuscript ID	18655
Country	Italy

Received	2015-04-26 14:25
Peer-Review Started	2015-04-28 09:29
To Make the First Decision	2015-06-02 16:06
Return for Revision	2015-06-08 17:06
Revised	2015-07-04 23:52
Second Decision	2015-08-19 15:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-02 15:14
Articles in Press	2015-09-02 15:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-21 10:12
Publish the Manuscript Online	2015-10-14 12:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Topic Highlights
Article Title	Hepatitis C virus markers in infection by hepatitis C virus: In the era of directly acting antivirals
Manuscript Source	Invited Manuscript
All Author List	Nicola Coppola, Mariantonietta Pisaturo, Rosa Zampino, Margherita Macera, Caterina Sagnelli and Evangelista Sagnelli
Funding Agency and Grant Number
Corresponding Author	Nicola Coppola, MD, PhD, Assistant Professor of Infectious Diseases, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Via L. Armanni 5, 80131 Naples, Italy. nicola.coppola@unina2.it
Key Words	Chronic hepatitis C; Hepatitis C virus replication; Directly acting antivirals; Staging; Hepatitis C virus infection
Core Tip	The second and third wave directly acting antivirals introduced in 2013-2014 enhanced the efficacy and tolerability of anti-hepatitis C virus (HCV) treatment. Consequently, the traditional indicators for disease management and predictors of treatment response should be revised in light of these new therapeutic options. This review article analyzes the modern use of the markers of HCV infection in: (1) the diagnosis of acute hepatitis C; (2) the diagnosis of chronic HCV infection; (3) the assessment of the severity of chronic hepatitis C; (4) the assessment of factors associated with response to anti-viral treatment; and (5) HCV-RNA kinetics and clearance as markers of remission.
Publish Date	2015-10-14 12:06
Citation	Coppola N, Pisaturo M, Zampino R, Macera M, Sagnelli C, Sagnelli E. Hepatitis C virus markers in infection by hepatitis C virus: In the era of directly acting antivirals. World J Gastroenterol 2015; 21(38): 10749-10759
URL	http://www.wjgnet.com/1007-9327/full/v21/i38/10749.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i38.10749

Full Article (PDF)	WJG-21-10749.pdf
Full Article (Word)	WJG-21-10749.doc
Manuscript File	18655-Review.docx
Answering Reviewers	18655-Answering reviewers.pdf
Audio Core Tip	18655-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	18655-Conflict-of-interest statement.pdf
Copyright License Agreement	18655-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18655-Language certificate.pdf
Peer-review Report	18655-Peer-review(s).pdf
Scientific Misconduct Check	18655-Scientific misconduct check.pdf
Scientific Editor Work List	18655-Scientific editor work list.pdf