| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Observational Study |
| Article Title |
Effectiveness of hepatitis B virus vaccination program in Egypt: Multicenter national project
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Iman I Salama, Samia M Sami, Zeinab Nabil Ahmed Said, Manal H El-Sayed, Lobna A El Etreby, Thanaa M Rabah, Dalia M Elmosalami, Amany T Abdel Hamid, Somaia I Salama, Aida M Abdel Mohsen, Hanaa M Emam, Safaa M Elserougy, Amal I Hassanain, Naglaa F Abd Alhalim, Fatma A Shaaban, Samia A Hemeda, Nihad A Ibrahim and Ammal M Metwally |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Development Fund (STDF), Egypt |
1611 |
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| Corresponding Author |
Zeinab Nabil Ahmed Said, Professor in Microbiology and Immunology Department, Faculty of Medicine (for girls), Al-Azhar University, Yousef Abbas Str, Nasr City, Cairo 11754, Egypt. znabil58@yahoo.com
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| Key Words |
Hepatitis B virus; Immunization; Sero-protection; Breakthrough infection; Children |
| Core Tip |
To assess the effectiveness of hepatitis B virus (HBV) vaccination program, a national community based survey was carried out in six governorates representing Egypt on 3600 children aged 9 mo to 16 years (received 3 doses HBV vaccine during infancy). Anti-hepatitis B surface (anti-HBs) titer, anti-HBc and HBs antigen were assessed. HBV DNA detection was done for suspected cases. Prevalence of HBV sero-protection, breakthrough HBV infection, and chronic carrier were 57.2% 0.39% and 0.11% respectively. Multivariate analysis revealed that older age and girls were the significant predictor variables for non sero-protection. Despite waning of anti-HBs over time, HBV vaccination program is effective in Egypt.
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| Publish Date |
2015-10-02 19:06 |
| Citation |
Salama II, Sami SM, Said ZNA, El-Sayed MH, El Etreby LA, Rabah TM, Elmosalami DM, Abdel Hamid AT, Salama SI, Abdel Mohsen AM, Emam HM, Elserougy SM, Hassanain AI, Abd Alhalim NF, Shaaban FA, Hemeda SA, Ibrahim NA, Metwally AM. Effectiveness of hepatitis B virus vaccination program in Egypt: Multicenter national project. World J Hepatol 2015; 7(22): 2418-2426 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i22/2418.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i22.2418 |
