Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	18687
Country	Australia

Received	2015-04-27 18:03
Peer-Review Started	2015-04-28 09:47
To Make the First Decision	2015-08-31 16:43
Return for Revision	2015-09-08 09:58
Revised	2015-09-23 07:32
Second Decision	2015-10-22 15:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-04 17:03
Articles in Press	2015-11-04 17:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-03 19:01
Publish the Manuscript Online	2015-12-14 21:02

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Management of asymptomatic primary tumours in stage IV colorectal cancer: Review of outcomes
Manuscript Source	Invited Manuscript
All Author List	Kate Jessica Wilkinson, Wei Chua, Weng Ng and Aflah Roohullah
Funding Agency and Grant Number
Corresponding Author	Dr. Kate Jessica Wilkinson, MBChB, Medical Oncology Advanced Trainee, Liverpool Cancer Therapy Centre, Liverpool Hospital, Corner of Elizabeth and Goulburn Streets, Liverpool, NSW 2170, Australia. kate.wilkinson@sswahs.nsw.gov.au
Key Words	Colorectal cancer; Resection; Primary tumour; Asymptomatic; Unresectable metastases; Chemo­therapy; Complications
Core Tip	The management of asymptomatic primary tumours in stage IV colorectal cancer is under debate. A literature review was performed focusing on this cohort, with patients undergoing primary tumour resection (PTR) vs up front chemotherapy. Survival appears equivalent with both management strategies, with a trend to an advantage in PTR. Surgical mortality is low and most morbidity transient. Most studies are retrospective, small and non-randomised. Larger randomised controlled trials are awaited.
Publish Date	2015-12-14 21:02
Citation	Wilkinson KJ, Chua W, Ng W, Roohullah A. Management of asymptomatic primary tumours in stage IV colorectal cancer: Review of outcomes. World J Gastrointest Oncol 2015; 7(12): 513-523
URL	http://www.wjgnet.com/1948-5204/full/v7/i12/513.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i12.513

Full Article (PDF)	WJGO-7-513.pdf
Full Article (Word)	WJGO-7-513.doc
Manuscript File	18687-Review.docx
Answering Reviewers	18687-Answering reviewers.pdf
Audio Core Tip	18687-Audio core tip.mp3
Biostatistics Review Certificate	18687-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	18687-Conflict-of-interest statement.pdf
Copyright License Agreement	18687-Copyright assignment.pdf
Peer-review Report	18687-Peer-review(s).pdf
Scientific Misconduct Check	18687-Scientific misconduct check.pdf
Scientific Editor Work List	18687-Scientific editor work list.pdf