Publication Name	World Journal of Gastroenterology
Manuscript ID	18688
Country	Slovenia

Received	2015-04-27 11:40
Peer-Review Started	2015-04-28 09:53
To Make the First Decision	2015-06-02 16:05
Return for Revision	2015-06-08 17:23
Revised	2015-06-19 03:19
Second Decision	2015-08-10 08:17
Accepted by Journal Editor-in-Chief	2015-08-11 15:12
Accepted by Executive Editor-in-Chief	2015-08-31 17:43
Articles in Press	2015-08-31 17:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-14 10:23
Publish the Manuscript Online	2015-09-28 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Challenges of deciphering gastric cancer heterogeneity
Manuscript Source	Invited Manuscript
All Author List	Petra Hudler
Funding Agency and Grant Number
Corresponding Author	Petra Hudler, PhD, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia. petra.hudler@mf.uni-lj.si
Key Words	Adenocarcinoma; Biological markers; Proteomics; Molecular diagnostics; DNA methylation; Histone modification; Genetic susceptibility
Core Tip	This article summarizes the evidence of heterogeneous gastric cancer molecular changes. Despite enormous research efforts, to date, none of the common DNA, RNA or protein aberrations have achieved the high sensitivities, specificities, and predictive values necessary for clinical utility. Complex interrogation schemes based on a systems medicine approach should be developed to determine effective therapeutic strategies and to identify molecular signatures that are specific for the early detection of gastric cancer and pre-malignant stomach lesions that could progress to malignant disease.
Publish Date	2015-09-28 18:06
Citation	Hudler P. Challenges of deciphering gastric cancer heterogeneity. World J Gastroenterol 2015; 21(37): 10510-10527
URL	http://www.wjgnet.com/1007-9327/full/v21/i37/10510.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i37.10510

Full Article (PDF)	WJG-21-10510.pdf
Full Article (Word)	WJG-21-10510.doc
Manuscript File	18688-Review.doc
Answering Reviewers	18688-Answering reviewers.pdf
Audio Core Tip	18688-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18688-Conflict-of-interest statement.pdf
Copyright License Agreement	18688-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18688-Language certificate.pdf
Peer-review Report	18688-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18688-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18688-Scientific misconduct check.pdf
Scientific Editor Work List	18688-Scientific editor work list.pdf