Publication Name	World Journal of Hepatology
Manuscript ID	18790
Country	Japan

Received	2015-04-28 18:00
Peer-Review Started	2015-05-01 17:31
To Make the First Decision	2015-07-27 16:11
Return for Revision	2015-08-04 08:44
Revised	2015-08-22 22:03
Second Decision	2015-09-28 14:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-13 17:21
Articles in Press	2015-10-13 17:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-15 09:27
Publish the Manuscript Online	2015-11-09 18:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Ribavirin contributes to eradicate hepatitis C virus through polarization of T helper 1/2 cell balance into T helper 1 dominance
Manuscript Source	Invited Manuscript
All Author List	Katsuhisa Nakatsuka, Masanori Atsukawa, Masumi Shimizu, Hidemi Takahashi and Chiaki Kawamoto
Funding Agency and Grant Number
Corresponding Author	Katsuhisa Nakatsuka, MD, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. kaynet@nms.ac.jp
Key Words	Ribavirin; Forkhead box-P3; T helper 1/2 cell balance; T-regulatory lymphocytes; Inducible co-stimulator; Interleukin-10; Hepatitis C virus infection
Core Tip	Ribavirin has the potential to regulate the T-helper (Th) 1/2 cell balance into Th1 dominance by modulating the co-stimulatory signaling between antigen-presenting cells and na?ve Th cells as well as the inhibitory activity of T-regulatory cells. These are considered useful in treating hepatitis C virus infection, especially to inhibit hepatocellular carcinoma development.
Publish Date	2015-11-09 18:35
Citation	Nakatsuka K, Atsukawa M, Shimizu M, Takahashi H, Kawamoto C. Ribavirin contributes to eradicate hepatitis C virus through polarization of T helper 1/2 cell balance into T helper 1 dominance. World J Hepatol 2015; 7(25): 2590-2596
URL	http://www.wjgnet.com/1948-5182/full/v7/i25/2590.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i25.2590

Full Article (PDF)	WJH-7-2590.pdf
Full Article (Word)	WJH-7-2590.doc
Manuscript File	18790-Review.docx
Answering Reviewers	18790-Answering reviewers.pdf
Audio Core Tip	18790-Audio core tip.amr
Conflict-of-Interest Disclosure Form	18790-Conflict-of-interest statement.pdf
Copyright License Agreement	18790-Copyright assignment.pdf
Peer-review Report	18790-Peer-review(s).pdf
Scientific Misconduct Check	18790-Scientific misconduct check.pdf
Scientific Editor Work List	18790-Scientific editor work list.pdf