Publication Name	World Journal of Gastroenterology
Manuscript ID	18813
Country	China

Received	2015-04-28 16:52
Peer-Review Started	2015-05-04 10:57
To Make the First Decision	2015-08-26 09:48
Return for Revision	2015-08-31 15:33
Revised	2015-09-28 08:49
Second Decision	2015-11-03 09:23
Accepted by Journal Editor-in-Chief	2015-11-05 12:41
Accepted by Executive Editor-in-Chief	2015-11-13 15:58
Articles in Press	2015-11-13 15:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-12-15 14:59
Typeset the Manuscript	2016-01-19 15:02
Publish the Manuscript Online	2016-01-31 11:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation
Manuscript Source	Invited Manuscript
All Author List	Xiao-Min Xu and Hong-Jie Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81270469
Corresponding Author	Hong-Jie Zhang, MD, PhD, Professor, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. hjzhang06@163.com
Key Words	Autoimmunity; Immune system; Inflam­mation; Inflammatory bowel disease; miRNA
Core Tip	Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation in the gastrointestinal tract, but its pathogenesis remains unclear. Further understanding of the molecular mechanisms of IBD is helpful to find new therapeutic strategies. miRNAs play crucial regulatory roles in immune cellular differentiation and maturation, and maintaining immune homeostasis. Aberrant expression of miRNAs is present in IBD. Here, we summarize how miRNAs regulate autoimmunity and inflammation, and describe specific miRNA expression profiles in IBD. We also discuss the opportunities in utilizing miRNAs as new biomarkers and potential therapeutic targets in IBD.
Publish Date	2016-01-31 11:48
Citation	Xu XM, Zhang HJ. miRNAs as new molecular insights into inflammatory bowel disease: crucial regulators in autoimmunity and inflammation. World J Gastroenterol 2016; 22(7): 2206-2218
URL	http://www.wjgnet.com/1007-9327/full/v22/i7/2206.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i7.2206

Full Article (PDF)	WJG-22-2206.pdf
Full Article (Word)	WJG-22-2206.doc
Manuscript File	18813-Review.doc
Answering Reviewers	18813-Answering reviewers.pdf
Audio Core Tip	18813-Audio core tip.wav
Conflict-of-Interest Disclosure Form	18813-Conflict-of-interest statement.pdf
Copyright License Agreement	18813-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18813-Language certificate.pdf
Peer-review Report	18813-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18813-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18813-Scientific misconduct check.pdf
Scientific Editor Work List	18813-Scientific editor work list.pdf