Publication Name	World Journal of Gastroenterology
Manuscript ID	18818
Country	Germany

Received	2015-04-28 16:44
Peer-Review Started	2015-05-04 11:00
First Decision by Editorial Office Director
Return for Revision	2015-09-14 21:03
Revised
Publication Fee Transferred
Second Decision by Editor	2015-11-03 09:22
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-11-13 15:59
Articles in Press	2015-11-13 15:59
Edit the Manuscript by Language Editor	2015-11-19 21:36
Typeset the Manuscript	2015-12-13 21:29
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Genetic variation of hepatitis B virus and its significance for pathogenesis
Manuscript Source	Invited Manuscript
All Author List	Zhen-Hua Zhang, Chun-Chen Wu, Xin-Wen Chen, Xu Li, Jun Li and Meng-Ji Lu
Funding Agency and Grant Number
Corresponding Author	Meng-Ji Lu, PhD, Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. mengji.lu@uni-due.de
Key Words	Hepatitis B virus; Genotype; Variation; Pathogenesis
Core Tip	Due to the unique life cycle of hepatitis B virus (HBV) which requires an error-prone reverse transcriptase for replication, it constantly evolves resulting in significant genetic variation in the form of genotype, sub-genotype, and mutations. A large number of publications on the relationship between HBV genetic variation and HBV-related pathogenesis have appeared in recent years. However, the progress in this field has not been reviewed. We have attempted to provide a brief account of the influence of HBV genotype and mutations in the different viral genome regions on HBV-associated pathogenesis. This review provides an overview for scientists working on HBV and related fields.
Publish Date	2015-12-31 13:27
Citation	Zhang ZH, Wu CC, Chen XW, Li X, Li J, Lu MJ. Genetic variation of hepatitis B virus and its significance for pathogenesis. World J Gastroenterol 2016; 22(1): 126-144
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/126.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.126

Full Article (PDF)	WJG-22-126.pdf
Full Article (Word)	WJG-22-126.doc
Manuscript File	18818-Review.docx
Answering Reviewers	18818-Answering reviewers.pdf
Audio Core Tip	18818-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18818-Conflict-of-interest statement.pdf
Copyright License Agreement	18818-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18818-Language certificate.pdf
Peer-review Report	18818-Peer-review(s).pdf
Scientific Misconduct Check	18818-Scientific misconduct check.pdf
Scientific Editor Work List	18818-Scientific editor work list.pdf